Guest guest Posted May 7, 2004 Report Share Posted May 7, 2004 From Medscape March 17, 2004 — Glucosamine has a disease-modifying effect on osteoarthrit= is, according to the results of two three-year randomized studies published in = the March/April issue of Menopause. " The management of knee osteoarthritis, recognized as responsible for consi= stent pain and disability, is a major social and economic target in health manage= ment, " write Olivier Bruyere, MSc, from the WHO Collaborating Center for Public He= alth Aspect of Osteoarticular Disorders in Liege, Belgium, and colleagues. " For = a few years, glucosamine sulfate has been considered a potential disease-modifying drug = for osteoarthritis. " This study was a preplanned combination of two three-year, randomized, plac= ebo- controlled, prospective, independent trials investigating the effects of gl= ucosamine sulfate on symptoms and joint structure in osteoarthritis. Of 414 subjects = enrolled, 319 were postmenopausal women. Demographics and disease characteristics wer= e similar at baseline in the glucosamine sulfate and placebo groups, both in = the overall study population and in the subgroup of postmenopausal women. After three years, postmenopausal women who received placebo had joint spac= e narrowing on standing anteroposterior knee radiographs, but those who recei= ved glucosamine did not. Joint space change was +0.003 mm (95% confidence inter= val [CI], -0.09 to 0.11) in the glucosamine group and -0.33 mm (95% CI, -0.44 t= o -0.22) in the placebo group (P < .0001). The glucosamine sulfate group also improved in the Western Ontario and McMa= ster Universities Osteoarthritis Index function scale (WOMAC) reflecting symptom= s (- 14.1%; 95% CI, -22.2 to -5.9), while there was a trend for worsening in the= placebo group (5.4%; 95% CI, -4.9 to 15.7; P = .003 between groups). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2004 Report Share Posted May 9, 2004 Any idea on dosage of glucosamine used? Ken Hoffman Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 10, 2004 Report Share Posted May 10, 2004 Any idea on dosage of glucosamine used? >>>The usual 1500 mg alon Quote Link to comment Share on other sites More sharing options...
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