A 21st century Understanding of Prostate Cancer

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Summary:

 

Treatment of prostate cancer involves a lottery where the patient almost

invariably loses out over time, but this need not be so.

 

For the last fifty years or more it has been widely recognised that some

androgen states cause prostate tumour proliferation and for this reason the

blocking of natural androgens has become one of the main treatment options

for the disease. This is particularly the case where primary treatments of

prostatic surgery or prostatic radiation have failed to remove the tumour

completely, and despite the fact that there is as yet no cure for advanced

prostate cancer.

 

This paper brings together notable case studies and selected literature over

the last half century and discusses three crucial factors that might be

applied to understanding the problem of prostate cancer in the 21st Century:

 

· Hormesis, or non-linear biological dose-response relationships;

 

· The Field Theory of carcinogenesis; and last but not least,

 

· The Bio-cultural Link in disease etiology.

 

In the literature reviewed a strategy for reduction of objective clinical

disease markers and symptoms was gleaned from observations and theoretical

considerations to provide a novel framework for understanding prostate

cancer

 

This represents an alternate paradigm for both prostate cancer etiology and

its treatment with curative intent.*

 

The author of this manuscript has based his own treatment around these

findings and has enjoyed a stable condition without any conventional

treatment since embarking on this novel pathway over a year ago. Bone

scintigraphy scans show no sign of metastases and Prostascint scans every

two years have shown no sign of recent progression. The author was diagnosed

in 1996 (age 49) including extreme perineal pain and urinary symptoms of

retention and urgency, a PSA over 50 ng/ml, a Gleason Score of 7 (3+4), and

a tumour stage of T3N0M0 prior to surgery. Post surgical biopsy of margins

around the area of resection were positive with evidence of lymph node and

seminal vesicle involvement. Repeated cycles of treatment showed no promise

of success until normal conventions were abandoned.

 

References:

 

* " For the simple truth is that truth is very often hard to come by, and

that once found it may easily be lost again. Erroneous beliefs may have an

astonishing power to survive, for thousands of years, in defiance of

experience, with or without the aid of conspiracy. The history of science,

and especially of medicine, could furnish us with a number of good

examples. " Karl Popper, from his lecture " On the Sources of Knowledge and

Ignorance " first delivered before the British Academy in 1960. Proc Br Ac

46.