Guest guest Posted January 11, 2005 Report Share Posted January 11, 2005 , " " <@e...> wrote: > Hi Daniel & DM, > > > hello group, i would appreciate any specific experience or > > reccomendations for prophelactic use of cm against malarial infection? > > thanks for your help, dm<<< > > Hello dm, There was a discussion on this list a few months back and, if I > remember correctly, there was some consensus that there may not be any > Chinese medicinals that could be used as prophylactic agents. I just found this today. In another article about the same study they combined curcumin, artemisinin and another anti-malarial drug. Sounds like the beginnings of a formula. I haven't found the full study yet. Jill Likkel Curcumin for malaria therapy Raju C. Reddya, Palakkodu G. Vatsalab, Venkateshwar G. Keshamounia, Govindarajan Padmanabanb and Pundi N. Rangarajanb, , aDepartment of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI 48109-0360, USA bDepartment of Biochemistry, Indian Institute of Science, Bangalore 560012, India Received 9 November 2004. Available online 20 November 2004. Abstract Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner with an IC50 of 5 ìM. Additionally, oral administration of curcumin to mice infected with malaria parasite (Plasmodium berghei) reduces blood parasitemia by 80–90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection. Keywords: Curcumin; Malaria; Plasmodium; Artemisinin Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2005 Report Share Posted January 11, 2005 , " Jill A. Likkel " <jilllikkel@h...> wrote: > > > Curcumin for malaria therapy > > Raju C. Reddya, Palakkodu G. Vatsalab, Venkateshwar G. Keshamounia, > Govindarajan Padmanabanb and Pundi N. Rangarajanb, , > > aDepartment of Internal Medicine, The University of Michigan Medical > School, Ann Arbor, MI 48109-0360, USA > bDepartment of Biochemistry, Indian Institute of Science, Bangalore > 560012, India I have the full article now if you want it email me. Jill Likkel Quote Link to comment Share on other sites More sharing options...
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