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> William Egloff <bill

> April 15, 2005 5:40:41 AM PDT

> <

> Crane : more on Ma Huang ruling

>

> AHPA Update • April 14, 2005

>

>

> Court Overturns FDA Ban on Low-dose Ephedra Products

>

>

> A United States District Court ruled yesterday that the Food and Drug

> Administration failed to prove that a dosage of 10 milligrams or less

> of

> ephedrine alkaloids presents an unreasonable risk of illness of injury

> when

> the agency banned all ephedrine-containing dietary supplements last

> year.

> The ruling has no effect on FDA’s ban on higher dose products, such as

> products that were formerly sold to promote weight loss.

> “This court has provided a rational opinion that the amount of an

> ingredient

> must be considered when evaluating the safety of that ingredient,”

> commented

> Michael McGuffin, AHPA president. “This is not a new idea. This has

> been the

> way we evaluate the ingredients we add to foods, the way we evaluate

> drug

> safety, and now it will be the way we evaluate the safety of dietary

> supplements. And what the court has said is that FDA needs to pay

> better

> attention to this detail.”

> Judge Tena Campbell ruled on a case brought by Nutraceutical

> Corporation and

> Solaray, Inc., who had filed suit against FDA last May to allege that

> FDA’s

> final rule on ephedrine alkaloids in dietary supplements was unlawful

> as

> applied to the company’s whole herb low ephedrine level product. In its

> lawsuit Nutraceutical Corporation stated that in order for FDA to

> completely

> ban an ingredient it bears the burden of proving that an ingredient

> presents

> an unreasonable or significant risk at every dose level and as

> labeled. The

> complaint also argued that when Congress passed the Dietary Supplement

> Health and Education Act it did not intend for FDA’s new authority to

> remove

> unsafe ingredients to be used to ban ingredients at every dosage level

> with

> no consideration of the use of warning labels.

> Yesterday’s District Court decision also concluded that FDA’s use of a

> risk-benefit analysis in determining an unreasonable risk of

> ephedrine-containing dietary supplements was “improper.” The Court

> explained

> that it is “contrary to the clear intent of Congress” to require

> marketers

> to demonstrate a benefit for their ephedra dietary supplements, as is

> implied by FDA’s use of a risk-benefit analysis. In addition, FDA was

> instructed by the court to consider further rulemaking “consistent

> with this

> Order” and to refrain from taking any enforcement action against

> Nutraceutical Corporation for their sale of products containing less

> than 10

> mg of ephedrine alkaloids. FDA was not, however, specifically

> instructed to

> refrain from acting against other brands that contain less than 10 mg

> of

> ephedrine while it reviews its current regulation.

> This case is Nutraceutical Corporation and Solaray, Inc., Plaintiffs,

> vs.

> Lester Crawford, D.V.M., Acting Commissioner, U.S. Food and Drug

> Administration, et al., Defendants, and can be downloaded at

> http://www.ahpa.org/05_0413_USDistrictCourt_Nutraceuticals.pdf.

>

>

>

>

>

 

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