The Effect of Chinese herbs on the Expression of Aquaporin

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The Effect of Chinese herbs on the Expression of Aquaporin

 

3,4 Gene in Gastric Mucosa of Patients with Pi-Wei Damp-Heat Syndrome

 

Chen GX, et al. Guangdong Provincial Hospital of Traditional Chinese

Medicine, Guangzhou. cgx0101

 

A study was conducted to examine the relationship between Pi-Wei

Damp-Heat Syndrome (PWDHS) with expression of aquaporin (AQP) 3,4 gene

in gastric mucosa and the effects of Qingre Huashi Recipe (QHR) on the

expression. A total of 68 patients with chronic superficial gastritis

were differentiated into Pi-Wei Damp-Heat Syndrome group (PWDHS, n =

53, 19 cases with predominant Dampness, 14 cases with predominant

Heat, 20 cases with Dampness equal to Heat) and Pi deficiency Syndrome

group (PDS, n = 15). The PWDHS group was treated with QHR. The

expression of AQP 3,4 gene in the two groups were verified by

fluorescence quantitative polymerase chain reaction (FQ-PCR). The

results of the study showed that expression of AQP 3 gene in PWDHS was

higher than that in PDS and the healthy group, but the difference

showed no statistical significance. Expression of AQP 4 gene in PWDHS

was obvious higher than that in PDS and the healthy group (P <0.05 or

P <0.01), but the difference of AQP 4 gene expression between PDS and

the healthy group was insignificant. Comparison among various

sub-types of PWDHS showed that the AQP 4 gene expression in the

predominant dampness > dampness equal to heat> predominant heat. AQP

3,4 gene expression in PWDHS was significantly decreased after QHR

treatment, especially in the cases with predominant dampness syndrome

(P <0.01), approaching that in the healthy group and PDS.

 

In conclusion, abnormal expression of AQP 3,4 gene may be one of the

possible mechanisms of PWDHS pathogenesis, and Chinese herbs could

influence AQP 3,4 gene expression to play a key role in treatment.

 

Tom.