Rehmannia and clottong on Medline

[Guest guest]

Hi All, & Al,

 

Al Stone wrote:

> Re: **JUNK** Re: Re: Herbal substitute for Coumadin I'm

> guessing that if we can wait for Phi ... he's going to locate some

> research citations that talks about Rehmannia and micro-circulation or

> something. That might be part of its stop bleeding mechanism, seems

> reasonable to me. -al.

 

I am just back after a seminar on veterinary acupuncture in Poland.

 

Medline has 7 hits for the profile:

(prothrombin OR bleeding OR hemorrha* OR haemorrha* OR thromb*

OR clotting) AND (Rehmannia OR rehmanniae OR dihuang OR

shengdi*)

 

Interpretation of the data in these hits is problematic because some

papers used formulas with multiple herbs and some suggest ANTI-

haemorrhagic (haemostatic) effects while others suggest ANTI-clotting

(Blood-moving) effects.

 

Phytother Res. 2005 Oct;19(10):846-53. Effects of traditional herbal

medicine, Hwaotang, on atherosclerosis using the spontaneous familial

hypercholesterolemia model, Kurosawa and Kusanagi-

hypercholesterolemic rabbits and the venous thrombosis rats. Park WH,

Hong MY, Chung KH, Kim HM, Lee YC, Kim CH. Department of

Biochemistry, Molecular Biology and Diagnosis, College of Oriental

Medicine, Dongguk University and National Research Laboratory for

Glycobiology, Korean Ministry of Science and Technology, Kyungbuk,

Korea. Hwaotang (HOT), a traditional Korean medicinal formulation, is a

dried decoctum of a mixture of seven herbal medicines, consisting of

Angelica gigantis Rx, Rehmanniae Rx, Paeoniae Rx, Ciniamomi Cx,

Cnidii Rz, Persicae S and Carthami Fl. In the present study, the

inhibitory effects and anti thrombic properties of HOT on the

progression of atherosclerotic lesions were studied using the

spontaneous familial hypercholesterolemia (FH) model, Kurosawa and

Kusanagi-hypercholesterolemic (KHC) rabbits and rats. Changes in

blood chemistry, pathology and low-density lipoprotein (LDL) oxidation

were measured in a control and HOT group. In the control group, the

area of atheromatous plaques of the aorta progressed between week

12 (36.65%) and week 14 (46.22%). This progression of atherosclerotic

lesions did not occur in the HOT-treated group after 12 (24.24%) and 14

(23.34%) weeks. Antioxidative effects on LDL were seen in the HOT in

weeks 12 and 14. HOT improved the hypercholesterolemia in the KHC

rabbits. On the other hand, HOT and five of the seven herbs, except

Cnidii Rz and Carthami Fl, inhibited the endotoxin-induced hepatic

venous thrombosis in high cholesterol diet-treated rats. However,

Ciniamomi Cx showed a very weak inhibitory effect on the endotoxin-

induced hepatic venous thrombosis. The extract also inhibited the

endotoxin-induced decrease in blood platelets and fibrinogen, and

endotoxin-induced increase in fibrin degradation products (FDP) on

disseminated intravascular coagulation in normal rats. In conclusion,

these results suggest that HOT has inhibitory effects on the

development of atheromatous plaque formation in spontaneous FH

rabbits. It is also suggested that the antioxidative effects of HOT on LDL

led to the beneficial effects observed in this study. The protection by

HOT and its herbs on the artificially induced ischemic infarction might

be related to their inhibitory effects on disseminated intravascular

coagulation, platelet coagulation and thrombotic action. Copyright ©

2005 John Wiley & Sons, Ltd. PMID: 16261513 [PubMed - indexed for

MEDLINE]

 

Vascul Pharmacol. 2005 Oct;43(4):283-8. Epub 2005 Oct 14. Anti-

thrombic activity of Korean herbal medicine, Dae-Jo-Whan and its

herbs. Chang GT, Min SY, Kim JH, Kim SH, Kim JK, Kim CH.

Department of Pediatrics, Dongguk University and National Research

Laboratory for Glycobiology and Cardiovascular Medical Research

Center, Sukjang-Dong 707, Kyungju City, Kyungbuk 780-714, South

Korea. The anti-thrombic properties of the Korean herbal medicine,

Dae-Jo-Hwan (DJW), which is consisted of 11 herbs (indicated as

concentrations) of Rehmanniae Rx 24%, Hominis placenta 5%,

Testudinis carapax 9%, Eucommiae Cx 9%, Asparagi Rx 9%,

Phellodendri Cx 9%, Achyranthis Rx 7%, Liriopis tuber 7%, Angelicae

sinensis Rx 7%, Ginseng Rx 6%, and Schizandrae Fr 3%, were

investigated. The extracts of DJW and its 11 herbs, except G. Rx, A.

sinensis Rx and S. Fr, inhibited the endotoxin-induced hepatic venous

thrombosis in high cholesterol diet-treated rats. Also the extract

inhibited the endotoxin-induced decrease in blood platelets and

fibrinogen, and endotoxin-induced increase in fibrin degradation

products (FDP) on disseminated intravascular coagulation in normal

rats. In in vitro experiments, the extract was shown to have inhibitory

effect on collagen- and ADP-induced blood platelet aggregation, on

thrombin-induced conversion of fibrinogen to fibrin and on the activity of

plasminogen or plasmin. In conclusion, the protection of extracts of

Korean herbs on the ischemic infarction induced artificially might be

related to their inhibitory effects on DIC, platelet coagulation and

thrombic action. PMID: 16226922 [PubMed - indexed for MEDLINE]

 

Am J Chin Med. 2005;33(1):21-7. Induction of apoptosis in human oral

cancer cell lines, OC2 and TSCCa, by chingwaysan. Liao PH, Chen SL,

Shih HC, Chou MY. Institute of Stomatology, Chung Shan Medical

University Hospital, Taichung, Taiwan. Chingwaysan, a Chinese herbal

formula, contains Cimicfugae Rz, Rehmanniae Rx et Rz, Moutan

Radicis Cx, Coptidis Rz and Angelicae Sinensis Rx. This medicine is

well-known for its curing power for ulcerated gums, toothaches, cheek

boils and bleeding gingiva. However, no reports can be found on its

application in the treatment of oral cancers. We are therefore interested

in whether Chingwaysan is capable of causing abnormal apoptosis

processes, and whether this condition can be rectified through

Chingwaysan herb treatment. We used aqueous extract to treat OC2

and TSCCa cells (both are human oral cancer cell lines) with different

Chingwaysan concentrations (0, 10, 25, 50, 75 and 100 microl/ml). The

MTT (3, (4, 5-dimethyl-thiazol) 2, 5-diphenyl-tetraxolium bromide)

reduction assay was employed to quantify the differences in cell activity

and viability. DNA ladder formation on agarose electrophoresis was also

performed. The bax expression level was monitored using

immunoblotting techniques. The patterns of the changes in expression

were scanned and analyzed by NIH image 1.56 software. Taken

together, drastic morphological changes, reduced cell viability and the

presence of inter-nucleosomal DNA fragmentation all indicated that

Chingwaysan is capable of inducing apoptosis in OC2 and TSCCa cell

lines. Furthermore, the accumulation of wild type bax protein

significantly increased in a dose-dependent manner upon treatment with

Chingwaysan. In conclusion, Chingwaysan can induce apoptosis via a

bax-dependent pathway in cells from these two particular oral cancer

cell lines. PMID: 15844830 [PubMed - indexed for MEDLINE]

 

Zhongguo Zhong Yao Za Zhi. 1999 Nov;24(11):663-6, 702. [A study on

hemostatic and immunological actions of fresh and dry Dihuang] [Article

in Chinese] Liang A, Xue B, Wang J, Hao J, Yang H, Yi H. Institute of

Chinese Materia Medica, China Academy of Traditional Chinese

Medicine, Beijing 100700. OBJECTIVE: To investigate the difference

between fresh and dry Dihuang (Rx Rehmanniae) in hemostatic and

immunological actions. METHODS: The hemostatic action was

assessed in aspirin-treated mice; immunological action was assessed

by phagocytosis of macrophages in dexamethasone-treated mice; and

Con A-induced mitogenesis and LPS-induced alkaline phosphatase

activity of splenocytes were determined in thyroxin-treated mice.

RESULT: The blood clotting in mice induced by aspirin was inhibited by

oral administrations of juice decoction of fresh Dihuang or decoction of

dry Dihuang alike. The action of fresh Dihuang juice was stronger than

that of dry Dihuang decoction. Oral administrarion of fresh Dihuang

juice or decoction for 10 days enhanced LPS-induced alkaline

phosphatase activity of splenocytes in thyroxin-treated mice. The juice

also enhanced Con A-induced splenocyte mitogenesis. The action of

dry Dihuang decoction was weaker than that of fresh juice in increasing

LPS-induced alkaline phosphatase activity. CONCLUSION: It is

recommended to follow the tradition of using fresh Dihuang juice or

decoction to treat some diseases such as hemorrhagenic troubles.

PMID: 12212085 [PubMed - indexed for MEDLINE]

 

Yakugaku Zasshi. 1996 Feb;116(2):158-68. [studies on Rehmanniae

Rx. III. The relation between changes of constituents and improvable

effects on hemorheology with the processing of roots of Rehmannia

glutinosa] [Article in Japanese] Kubo M, Asano T, Matsuda H, Yutani S,

Honda S. Faculty of Pharmaceutical Sciences, Kinki University, Japan.

The relation between constituents and effects on hemorheology with

processing of root of Rehmannia glutinosa was investigated. With the

processing to dried or steamed root from crude root, the content of

stachyose, which was the highest component in crude root, was

decreased and the content of manninotriose was increased. Iridoid

glycoside, catalpol, was gradually decreased with the processing. From

these results, the content of carbohydrates and catalpol made it

possible to estimate the quality of Rehmanniae Rx by processings. On

the other hand, the change of pharmacological activities with the

processing was investigated. The 50% ethanolic extract (BJ-ext) from

steamed root of R. glutinosa increased erythrocyte deformability and

erythrocyte ATP contents, inhibited polybrene-induced erythrocyte

aggregation, and promoted an activity of fibrinolytic system. The

extracts from crude or dried root had weak or no effect. The crude or

dried root and steamed root of R. glutinosa showed the different

pharmacological activities, and the quality of Rehamanniae Rx by

processings may be estimated by investigation of correlation between

the changes of constituents and improvable effects of hemorheology.

PMID: 8717282 [PubMed - indexed for MEDLINE]

 

Zhongguo Zhong Yao Za Zhi. 1992 Jun;17(6):366-8, inside backcover.

[studies of Rehmannia glutinosa Libosch. f. hueichingensis as a blood

tonic] [Article in Chinese] Yuan Y, Hou S, Lian T, Han Y. Henan College

of the Traditional , Zhengzhuo. We have studied the

function of dried and prepared Rehmannia glutinosa f. hueichingensis in

treating hemorrhagic anemic mice and in fostering bone marrow

hematopoietic cells CFU-S, CFU-E. The results show that Rehmannia

glutinosa f. hueichingensis can promote the recovery of blood deficient

animals, RBC. Hb expedite the multiplication and differentiation of CFU-

S, CFU-E, and thus proves markedly helpful to the generation of blood.

PMID: 1418586 [PubMed - indexed for MEDLINE]

 

Zhong Xi Yi Jie He Za Zhi. 1991 Jan;11(1):14-6, 3. [idiopathic

thrombocytopenic purpura in children treated with replenishing qi and

tonifying kidney and the changes in thrombocyte aggregative function]

[Article in Chinese] Shi YM, Wu QZ. Institute of TCM-WM, Children's

Hospital, Shanghai Medical University. 41 children with idiopathic

thrombocytopenic purpura (ITP) were reported in this paper. Of all, 36

with petechia and ecchymosis, 28 with nasal hemorrhage, 5 with

hematochezia and 1 with subcutaneous hematoma. According to the

TCM differentiation, 24 and 17 of all belonged to the type of impairment

of Yin due to blood-heat and both deficiencies of Qi and tonifying Kidney

and its basic prescriptions were: dried Rx Rehmanniae, Rx Angelicae

Sinensis, Rx Paeoniae Rubra, Rx Rubiae, Fr Psoraleae, stir-frying Rx

Astragali, S Cuscutae, Caulis Spatholob; Chinese Jujubae, Rx et Rz

Rhei. The average treating duration was 5.02 months. Results: 24

cases cured, 6 recovered, 10 improved, 1 failed, with a total effective

rate of 97.6%. 22 of the cured were followed-up without recurrence in

average 10.4 months after withdrawal. In 32 cases, the thrombocyte

aggregative function was tested with ADP induction, meanwhile in 20 of

32 cases aggregation with adrenaline induction was tested. The results

before and after treatment showed an evident difference, with low

function before treatment and normal after treatment. It is concluded

that the replenishing Qi and tonifying Kidney may have a better effect on

both acute and chronic children ITP without recurrence after withdrawal.

PMID: 2054885 [PubMed - indexed for MEDLINE]

 

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