Tamoxifen & herbs

[Guest guest]

Hi Alex, & All,

 

Alex Berks wrote:

> I reposted my earlier post about tamoxifen and herbs with footnotes at

> http:// www.healthwithcancer.blogspot.com Alex Berks L. Ac.

 

The soy isoflavone daidzein improves the capacity of tamoxifen to

prevent mammary tumours. Eur J Cancer. 2005 Mar;41(4):647-54.

Epub 2005 Jan 18. The aim of this study was to determine how the

efficacy of tamoxifen is affected when combined with soy isoflavones.

To address this, female Sprague-Dawley rats were placed on diets

supplemented with tamoxifen, genistein, daidzein, or a combination of

each isoflavone with tamoxifen; a week later mammary tumours were

induced by 7,12 dimethylbenzanthracene. The most effective diet was

the tamoxifen/daidzein combination. It reduced tumour multiplicity by

76%, tumour incidence by 35%, tumour burden by >95%, and increased

tumour latency by 62% compared with positive controls. The

tamoxifen/daidzein combination diet was in all aspects more effective

while the tamoxifen/genistein combination was less effective than the

tamoxifen diet. The tamoxifen/daidzein diet significantly decreased 8-

oxo-deoxyguanosine levels (an indicator of oxidative DNA damage) in

the mammary glands. This study conclusively shows for the first time

the combination of daidzein with tamoxifen produces increased

protection against mammary carcinogenesis, while the combination of

genistein with tamoxifen produces an opposing effect when compared

with tamoxifen alone.

 

Best regards,