Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 In looking around pubmed I found the difference between FAHF-1 and FAHF-2 is the removal of xi xin and fu zi but there is no listing of the herbs. Does anyone know what it is? Herbal formula silences peanut allergy in mice Last Updated: 2006-03-08 13:45:24 -0400 (Reuters Health) By Megan Rauscher NEW YORK (Reuters Health) - Treatment of peanut allergic mice with the Chinese herbal formula known as FAHF-2 completely blocks peanut-induced allergic reactions for up to 6 months following therapy and full protection is restored following a second course of FAHF-2, investigators report. These observations, if reproducible in humans, suggest that this Chinese herbal formula may be a highly effective treatment for peanut allergy, study investigators say. The findings were presented Tuesday in Miami at the American Academy of Allergy, Asthma and Immunology's annual meeting. Following treatment with FAHF-2 for 7 weeks, peanut-allergic mice were completely protected against peanut-induced reactions following oral challenges administered up to 34 weeks after treatment, lead investigator Dr. Kamal D. Srivastava from Mount Sinai School of Medicine in New York reported. Subsequent challenges at week 40 and 50 showed " only modest declines " in protection, the team reports, with 1 in 10 mice reacting to peanut challenge at week 40 and 3 in 10 at week 50. Full protection was restored with re-treatment with FAHF-2; no mouse reacted to oral peanut challenge administered at week 66. " This is a significant finding in terms of the duration of protection with a single course of treatment that can be taken orally, making it an effective and convenient treatment that can be administered at home, " Srivastava told Reuters Health. The research team is working to identify the bioactive compounds present in the formula. How FAHF-2 works remains unclear. Preliminary work indicates that FAHF-2 may target multiple cell types known to be involved in allergic reactions. FAHF-2 also appears to stimulate T cells to produce more interferon-gamma, a cytokine that is known to curb allergic responses. " There maybe other effects and more work needs to be done, " Srivastava acknowledged. " Another priority, " said Srivastava, " is to optimize the treatment course for human clinical trials and we look forward to submitting an IND (Investigational New Drug application) to the FDA in the near future. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 Herbs that fight nut allergy disclosed By Terry Murray NEW YORK – The formula has been revealed, 12 months later—the names of 11 Chinese herbs reported at the AAAAI meeting last year to have a striking effect on peanut allergy in a mouse model. Dr. Xiu-Min Li, assistant professor of pediatrics and clinical immunology at the Mount Sinai School of Medicine here, told the conference last year that the herbal formula reduced peanut-specific IgE levels in the mice by more than 30% and protected the animals from anaphylaxis. However, neither she nor another investigator on the project would reveal the contents of the formulation (see Medical Post, April 17, 2001). But in a seminar on alternative therapies in food allergy at this year's conference, Dr. Li named the contents. She listed the components of FAHF-1 (or food allergy herbal formula 1) first by their traditional Chinese medicine designation (in Pinyin), followed by the equivalent pharmaceutical name: • Ling zhi (Chi), or Ganoderma lucidum; • Fu zi (zhi), or Radix lateralis aconiti carmicaeli praeparata; • Wu mei, or Fructus pruni mume; • Chuan jiao, or Pericarpium zanthoxyli bungeani; • Xi xin, or Herba cum radice asari; • Huang lian (Chuan), or Rhizoma coptidis; • Huang bai, or Cortex phellodendri; • Gan jiang, or Rhizoma zingiberis officinalis; • Gui zhi, or Ramulus cinnamomi cassiae; • Ren shen (Hong), or Radix ginseng; and • Dang gui (shen), or Corpus radix angelicae sinensis. The Mt. Sinai researchers are working to standardize FAHF-1, to explore the way in which it suppresses allergic reactions and to determine the best combination of the 11 ingredients, Dr. Li said. They have also moved " one step closer to clinical study " by starting to evaluate FAHF-1 with human mucosal lymphocytes from four milk-allergic patients, she added. But she said only that in cell culture, FAHF-1 produced a " clear reduction " in proliferation and in IL-4 and IL-13, but did not alter interferon-gamma production. , " Alex Berks " <aberks wrote: > > In looking around pubmed I found the difference between FAHF-1 and > FAHF-2 is the removal of xi xin and fu zi but there is no listing of > the herbs. Does anyone know what it is? > > Herbal formula silences peanut allergy in mice > > Last Updated: 2006-03-08 13:45:24 -0400 (Reuters Health) > > By Megan Rauscher > > NEW YORK (Reuters Health) - Treatment of peanut allergic mice with the > Chinese herbal formula known as FAHF-2 completely blocks > peanut-induced allergic reactions for up to 6 months following therapy > and full protection is restored following a second course of FAHF-2, > investigators report. > > These observations, if reproducible in humans, suggest that this > Chinese herbal formula may be a highly effective treatment for peanut > allergy, study investigators say. The findings were presented Tuesday > in Miami at the American Academy of Allergy, Asthma and Immunology's > annual meeting. > > Following treatment with FAHF-2 for 7 weeks, peanut-allergic mice were > completely protected against peanut-induced reactions following oral > challenges administered up to 34 weeks after treatment, lead > investigator Dr. Kamal D. Srivastava from Mount Sinai School of > Medicine in New York reported. > > Subsequent challenges at week 40 and 50 showed " only modest declines " > in protection, the team reports, with 1 in 10 mice reacting to peanut > challenge at week 40 and 3 in 10 at week 50. > > Full protection was restored with re-treatment with FAHF-2; no mouse > reacted to oral peanut challenge administered at week 66. > > " This is a significant finding in terms of the duration of protection > with a single course of treatment that can be taken orally, making it > an effective and convenient treatment that can be administered at > home, " Srivastava told Reuters Health. > > The research team is working to identify the bioactive compounds > present in the formula. > > How FAHF-2 works remains unclear. Preliminary work indicates that > FAHF-2 may target multiple cell types known to be involved in allergic > reactions. > > FAHF-2 also appears to stimulate T cells to produce more > interferon-gamma, a cytokine that is known to curb allergic responses. > " There maybe other effects and more work needs to be done, " Srivastava > acknowledged. > > " Another priority, " said Srivastava, " is to optimize the treatment > course for human clinical trials and we look forward to submitting an > IND (Investigational New Drug application) to the FDA in the near future. " > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 Hey Doug, Just curious, looking at this formula, can you see any benefit to a patient with peanut allergies' symptoms? • Ling zhi (Chi), or Ganoderma lucidum; > • Fu zi (zhi), or Radix lateralis aconiti carmicaeli praeparata; > • Wu mei, or Fructus pruni mume; > • Chuan jiao, or Pericarpium zanthoxyli bungeani; > • Xi xin, or Herba cum radice asari; > • Huang lian (Chuan), or Rhizoma coptidis; > • Huang bai, or Cortex phellodendri; > • Gan jiang, or Rhizoma zingiberis officinalis; > • Gui zhi, or Ramulus cinnamomi cassiae; > • Ren shen (Hong), or Radix ginseng; and > • Dang gui (shen), or Corpus radix angelicae sinensis. > -- Pain is inevitable, suffering is optional. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 26, 2006 Report Share Posted April 26, 2006 Not really, but if I were a rat living in a cage I guess this would make me feel darn sparky. doug , " Al Stone " <al wrote: > > Hey Doug, > > Just curious, looking at this formula, can you see any benefit to a patient > with peanut allergies' symptoms? > > ? Ling zhi (Chi), or Ganoderma lucidum; > > ? Fu zi (zhi), or Radix lateralis aconiti carmicaeli praeparata; > > ? Wu mei, or Fructus pruni mume; > > ? Chuan jiao, or Pericarpium zanthoxyli bungeani; > > ? Xi xin, or Herba cum radice asari; > > ? Huang lian (Chuan), or Rhizoma coptidis; > > ? Huang bai, or Cortex phellodendri; > > ? Gan jiang, or Rhizoma zingiberis officinalis; > > ? Gui zhi, or Ramulus cinnamomi cassiae; > > ? Ren shen (Hong), or Radix ginseng; and > > ? Dang gui (shen), or Corpus radix angelicae sinensis. > > > > -- > > Pain is inevitable, suffering is optional. > > > Quote Link to comment Share on other sites More sharing options...
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