Rosemary, Cineole (Rosmarinus officinalis)

[Guest guest]

Butch Owen <butchbsi

Thu, 06 Nov 2003 21:19:48 -0800

Rosemary, Cineole (Rosmarinus officinalis)

 

 

Hi y'all,

 

I've been pushing Rosemary for a long time .. Martin has written a lot

and I've written a lot to dispel the many rumors and misinformation of

Rosemary raising BP and inducing seizures .. total bovine excrement it

is .. in fact, Rosemary has historically been used to STOP epilepsy

induced seizures. I use it often for colds, flu, etc., sometimes as a

cocktail with my favorites .. the Origanums. Here's a bit of info on

the power of this oil for liver problems. Granted, the study uses rats

so take it or leave it.

 

Y'all keep smiling, Butch :-) http://www.AV-AT.com

-------------------

Journal of Ethnopharmacology

Volume 81, Issue 2, pp. 145 - 154, July, 2002

 

Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in

the alleviation of carbon tetrachloride-induced acute hepatotoxicity in

the rat.

 

Authors

 

J.I. Sotelo-Felix, D. Martinez-Fong, P. Muriel, R.L. Santillan, D.

Castillo, P. Yahuaca

 

Abstract

 

The effect of oral administration of Rosmarinus officinalis L.

(Lamiaceae) on CCl4-induced acute liver injury was investigated.

 

Rats were daily treated with the plant extract at a dose of 200 mg/kg

corresponding to 6.04 mg/kg of carnosol as determined by reverse phase

high-performance liquid chromatography. The treatment was initiated 1 h

after CCl4 administration and Rosmarinus officinalis fully prevented

CCl4 effect on hepatic lipid peroxidation after 24 h of CCl4

administration. The increase in bilirubin level and alanine

aminotransferase activity in plasma induced by CCl4 was completely

normalized by Rosmarinus officinalis. The treatment also produced a

significant recovery of CCl4-induced decrease in liver glycogen content.

CCl4 did not modify the activity of liver cytosolic glutathione

S-transferase (GST) compared with that of control groups. However,

Rosmarinus officinalis increased liver cytosolic GST activity and

produced an additional increment in plasma GST activity in rats

treated with CCl4. Histological evaluation showed that Rosmarinus

officinalis partially prevented CCl4-induced inflammation, necrosis and

vacuolation. Rosmarinus officinalis might exert a dual effect on

CCl4-induced acute liver injury, acting as an antioxidant and improving

GST dependent detoxification systems.

 

Keywords: Antioxidant, Scavenger, Free radicals, Hepatoprotector

 

PII: s0378874102000909

 

© Copyright 1999-2003, Elsevier Science, All rights reserved.