Guest guest Posted May 22, 2006 Report Share Posted May 22, 2006 Journal of Ethnopharmacology Volume 81, Issue 2, pp. 161 - 164, July, 2002 Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats Authors M. El-Dakhakhny, N.J. Madi, N. Lembert, H.P.T. Ammon Abstract In the present study, Nigella sativa oil (NSO), nigellone (polythymoquinone) and derived thymoquinone were studied to evaluate their effect on the formation of 5-lipoxygenase (5-LO) products from polymorphonuclear leukocytes (PMNL).NSO produced a concentration dependent inhibition of 5-LO products and 5-hydroxy-eicosa-tetra-enoic acid (5-HETE) production with half maximal effects (IC50) at 25+/-1 µg/ml, respectively 24+/-1 µg/ml. Nigellone caused a concentration related inhibition of 5-HETE production (IC50: 11.9+/-0.3 µg/ml). Moreover thymoquinone, the active principle of NSO inhibited the production of 5-LO products (IC50: 0.26+/-0.02 µg/ml) and 5-HETE production (IC50: 0.36+/-0.02 µg/ml) in a similar way. The effects are probably due to an antioxidative action. The data may in part explain the effect of the oil, its derived thymoquinone and nigellone in ameliorating inflammatory diseases. Keywords: Nigella sativa, Nigellone, Thymoquinone, 5-LO products PII: s037887410200051x © Copyright 1999-2003, Elsevier Science, All rights reserved. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.