Rosemary, Cineole (Rosmarinus officinalis)

[Guest guest]

Hi y'all,

 

I've been pushing Rosemary as a super essential oil for a long time ..

Martin has written a lot and I've written a lot to dispel the many

rumors and misinformation of Rosemary raising BP and inducing seizures

... total bovine excrement it is .. in fact, Rosemary has historically

been used to STOP epilepsy induced seizures. I use it often for

colds, flu, etc., sometimes as a cocktail with my favorites .. the

Origanums. Here's a bit of info on the power of this oil for liver

problems. Granted, the study uses rats so take it or leave it.

 

Y'all keep smiling, Butch http://www.AV-AT.com

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Journal of Ethnopharmacology

Volume 81, Issue 2, pp. 145 - 154, July, 2002

 

Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae)

in the alleviation of carbon tetrachloride-induced acute

hepatotoxicity in the rat.

 

Authors

 

J.I. Sotelo-Felix, D. Martinez-Fong, P. Muriel, R.L. Santillan, D.

Castillo, P. Yahuaca

 

Abstract

 

The effect of oral administration of Rosmarinus officinalis L.

(Lamiaceae) on CCl4-induced acute liver injury was investigated.

 

Rats were daily treated with the plant extract at a dose of 200 mg/kg

corresponding to 6.04 mg/kg of carnosol as determined by reverse phase

high-performance liquid chromatography. The treatment was initiated 1h

after CCl4 administration and Rosmarinus officinalis fully prevented

CCl4 effect on hepatic lipid peroxidation after 24 h of CCl4

administration. The increase in bilirubin level and alanine

aminotransferase activity in plasma induced by CCl4 was completely

normalized by Rosmarinus officinalis. The treatment also produced a

significant recovery of CCl4-induced decrease in liver glycogen content.

 

CCl4 did not modify the activity of liver cytosolic glutathione

S-transferase (GST) compared with that of control groups. However,

Rosmarinus officinalis increased liver cytosolic GST activity and

produced an additional increment in plasma GST activity in rats

treated with CCl4. Histological evaluation showed that Rosmarinus

officinalis partially prevented CCl4-induced inflammation, necrosis

and vacuolation. Rosmarinus officinalis might exert a dual effect on

CCl4-induced acute liver injury, acting as an antioxidant and

improving GST dependent detoxification systems.

 

Keywords: Antioxidant, Scavenger, Free radicals, Hepatoprotector

 

PII: s0378874102000909

 

© Copyright 1999-2003, Elsevier Science, All rights reserved.