Pseudolymphoma Induced by Black Cohosh?

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Meyer S, Vogt T, Obermann EC, Landthaler M, Karrer S. Cutaneous

Pseudolymphoma Induced by Cimicifuga racemosa. Dermatology.

2007;214(1):94-6. Department of Dermatology, University of Regensburg,

Regensburg, Germany. We report a 56-year-old female patient who

presented with asymptomatic, localized erythematous plaques on arms and

legs. Histologically, the diagnosis of pseudolymphoma (PL) was confirmed.

Because of menopausal complaints, the patient had been taking

Remifemin®, a phytotherapeutical agent containing a standardized extract

of black cohosh (Cimicifuga racemosa) rhizome for 1 year. Six months after

initial administration of this herbal drug, first skin lesions appeared which

continuously increased. Withdrawal of Remifemin resulted in regression and

complete remission of the lesions within 12 weeks. To the best of our

knowledge, this is the first report on cutaneous PL induced by a

standardized extract of C. racemosa rhizoma. Thus, though claimed to be

poor in adverse effects, the potency of phytotherapeutical agents to induce

uncommon cutaneous eruptions needs to be taken into careful

reconsideration since the course of cutaneous PL tends to be chronic and

indolent if the causative agent is not discontinued. Copyright © 2007 S.

Karger AG, Basel. PMID: 17191056 [PubMed - in process]

 

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