Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 I'm looking for some good research articles on CM for the treatment of side effects of interferon (in Hep C tx). Either acupuncture or medicinal therapy would be fine, but preferably something that can ultimately be traced to a primary source of some type (journal, etc). I looked on Blue Poppy online and Pubmed, but no luck so far. Eric Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 Please share with all of us Also, any info on how people are treating Pt with Hep C on interferon would be appreciated - Eric Brand Monday, March 12, 2007 11:22 AM Hep C and Interferon I'm looking for some good research articles on CM for the treatment of side effects of interferon (in Hep C tx). Either acupuncture or medicinal therapy would be fine, but preferably something that can ultimately be traced to a primary source of some type (journal, etc). I looked on Blue Poppy online and Pubmed, but no luck so far. Eric Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 Hi! Eric, You can find at least 160 articles, if you type " Hepatitis C and interferon side effect treatment " in PubMed. Please let me know if you need additional help. Ta-Ya Ta-Ya Lee, MSN, CRNP, MAc, LAc, MBA Johns Hopkins Community Physicians Wyman Park Internal Medicine Phone 410-338-3421 Fax 410-338-3413 WARNING: E-mail sent over the Internet is not secure. Information sent by e-mail may not remain confidential. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 I've only seen one Chinese study (which I can't dig up now) that says treatment with herbs can provide additional success in the interferon treatment. You might check these guys, who have not published in English, except perhaps through Bob Flaws's translations - Qi Jing, Guan You Bo (Beijing TCM Hospital, Beijing 100010). In English I would pursue Matthew Dolan www.hepchandbook.com who works with John Tindall (Adjunct herbal formula) to see if there are any published trials. Sorry I can't be more helpful but I'll check through my notes. Doug , " Eric Brand " <smilinglotus wrote: > > I'm looking for some good research articles on CM for the treatment of > side effects of interferon (in Hep C tx). Either acupuncture or > medicinal therapy would be fine, but preferably something that can > ultimately be traced to a primary source of some type (journal, etc). > I looked on Blue Poppy online and Pubmed, but no luck so far. > > Eric > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 Misha Why do you discontinue silymarin and st. John's Wort prior to interferon? Pt tend to get derepressed - Ta-Ya Lee Monday, March 12, 2007 1:40 PM Re: Hep C and Interferon Hi! Eric, You can find at least 160 articles, if you type " Hepatitis C and interferon side effect treatment " in PubMed. Please let me know if you need additional help. Ta-Ya Ta-Ya Lee, MSN, CRNP, MAc, LAc, MBA Johns Hopkins Community Physicians Wyman Park Internal Medicine Phone 410-338-3421 Fax 410-338-3413 WARNING: E-mail sent over the Internet is not secure. Information sent by e-mail may not remain confidential. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 Anyone knows the ingredients of Fuzheng Jiedu Tang - Ta-Ya Lee Monday, March 12, 2007 1:40 PM Re: Hep C and Interferon Hi! Eric, You can find at least 160 articles, if you type " Hepatitis C and interferon side effect treatment " in PubMed. Please let me know if you need additional help. Ta-Ya Ta-Ya Lee, MSN, CRNP, MAc, LAc, MBA Johns Hopkins Community Physicians Wyman Park Internal Medicine Phone 410-338-3421 Fax 410-338-3413 WARNING: E-mail sent over the Internet is not secure. Information sent by e-mail may not remain confidential. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 12, 2007 Report Share Posted March 12, 2007 Éú»ÆÜÎ30 g£¬µ³²Î15 g£¬Éú°×Êõ10 g£¬ÜòÜß15 g£¬Òð³Â15 g£¬»¢ÕÈ15 g£¬Æѹ«Ó¢30 g£¬°ë±ßÁ«15 g£¬µ¤²Î15 g£¬ºì»¨5 g£¬ÉßÉà²Ý30 g£¬¸Ê²Ý6 g¡£ Or, if you can't read Chinese: Sheng Huang Qi 30g, Dang Shen 15g, Sheng Bai Zhu 10g, Fu Ling 15g, Yin Chen 15g, Hu Zhang 15g, Pu Gong Ing 30g, Ban Bian Lian 15g, Hong Hua 5g, She She Cao 30g, Gan Cao 6g. Mike L. Alon Marcus <alonmarcus wrote: Anyone knows the ingredients of Fuzheng Jiedu Tang - Ta-Ya Lee Monday, March 12, 2007 1:40 PM Re: Hep C and Interferon Hi! Eric, You can find at least 160 articles, if you type " Hepatitis C and interferon side effect treatment " in PubMed. Please let me know if you need additional help. Ta-Ya Ta-Ya Lee, MSN, CRNP, MAc, LAc, MBA Johns Hopkins Community Physicians Wyman Park Internal Medicine Phone 410-338-3421 Fax 410-338-3413 WARNING: E-mail sent over the Internet is not secure. Information sent by e-mail may not remain confidential. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 thanks - Mike Liaw Monday, March 12, 2007 10:25 PM Re: Hep C and Interferon Éú»ÆÜÎ30 g£¬µ³²Î15 g£¬Éú°×Êõ10 g£¬ÜòÜß15 g£¬Òð³Â15 g£¬»¢ÕÈ15 g£¬Æѹ«Ó¢30 g£¬°ë±ßÁ«15 g£¬µ¤²Î15 g£¬ºì»¨5 g£¬ÉßÉà²Ý30 g£¬¸Ê²Ý6 g¡£ Or, if you can't read Chinese: Sheng Huang Qi 30g, Dang Shen 15g, Sheng Bai Zhu 10g, Fu Ling 15g, Yin Chen 15g, Hu Zhang 15g, Pu Gong Ing 30g, Ban Bian Lian 15g, Hong Hua 5g, She She Cao 30g, Gan Cao 6g. Mike L. Alon Marcus <alonmarcus wrote: Anyone knows the ingredients of Fuzheng Jiedu Tang - Ta-Ya Lee Monday, March 12, 2007 1:40 PM Re: Hep C and Interferon Hi! Eric, You can find at least 160 articles, if you type " Hepatitis C and interferon side effect treatment " in PubMed. Please let me know if you need additional help. Ta-Ya Ta-Ya Lee, MSN, CRNP, MAc, LAc, MBA Johns Hopkins Community Physicians Wyman Park Internal Medicine Phone 410-338-3421 Fax 410-338-3413 WARNING: E-mail sent over the Internet is not secure. Information sent by e-mail may not remain confidential. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 , " Alon Marcus " <alonmarcus wrote: > > Misha > Why do you discontinue silymarin and st. John's Wort prior to interferon? Pt tend to get derepressed Sorry, I didn't catch that message? I know that Misha Cohen knows a lot about this topic, but I've been unable to reach her. Eric Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Is it still prevailing wisdom that Xiao Chai Hu Tang is contraindicated for patients undergoing interferon Tx? Geoff , " Eric Brand " <smilinglotus wrote: > > , " Alon Marcus " > <alonmarcus@> wrote: > > > > Misha > > Why do you discontinue silymarin and st. John's Wort prior to > interferon? Pt tend to get derepressed > > Sorry, I didn't catch that message? I know that Misha Cohen knows a > lot about this topic, but I've been unable to reach her. > > Eric > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Someone (I forget who) requested to hear about experiences of treating Hep C patients on interferon. I had one a few years ago, who was on combined interferon and ribavirin therapy. A few days after starting her treatments, she broke out in a full-body, deep red, itchy, weepy rash. I don't remember what I did with needles other than Sp-10 and LI-11, but when she left my office, you couldn't tell she had ever had that rash, except for the places where she scratched it and it had scabbed over. It was one of those confirming experiences early in my practice, when so much seemed beyond my total comprehension, that kept me going. The patient was a breast cancer survivor and had also just started graduate school. After a few weeks, she discontinued treatment, feeling overwhelmed by the memories of cancer stirred by her new illness, and by the demands of her studies.. Sucker-punch spam with award-winning protection. Try the free Mail Beta. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 , " Eric Brand " <smilinglotus wrote: > > I'm looking for some good research articles on CM for the treatment of > side effects of interferon (in Hep C tx). Either acupuncture or > medicinal therapy would be fine, but preferably something that can > ultimately be traced to a primary source of some type (journal, etc). > I looked on Blue Poppy online and Pubmed, but no luck so far. > > Eric > Eric, have you tried searching wanfangdata? There are many hits for interferon, hepatitis and zhenjiu/ zhongyao. If you want specific articles that you are unable to download, please send me a message. Tom. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Yes, Chai Hu raises the natural interferon levels and those on interferon therapy can overdose. This was the cause of the many deaths in Japan a few years ago. doug , " G Hudson " <crudo20 wrote: > > Is it still prevailing wisdom that Xiao Chai Hu Tang is > contraindicated for patients undergoing interferon Tx? > > Geoff > > , " Eric Brand " > <smilinglotus@> wrote: > > > > , " Alon Marcus " > > <alonmarcus@> wrote: > > > > > > Misha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 For those who are interested in clinical research on xiao chai hu tang and its reported interaction with interferon in Japan (it spells in Japanese as sho-saiko-to), I have published a review paper on Herbalgram on the Feburary issue (http://herbalgram.com/herbalgram/), thoroughly summerized over 50 medical journal publications. You can check this link and see if the journal is still having it free for the public: http://herbalgram.com/herbalgram/articleview.asp?a=3087 My paper is entitled: Sho-saiko-to, A Clinically Documented Herbal Preperation for Treating Chronic Liver Disease. You can also email me and request the PDF version of the paper. Dan Wen / Honso USA, Inc. , " " wrote: > > Yes, Chai Hu raises the natural interferon levels and those on interferon therapy can > overdose. This was the cause of the many deaths in Japan a few years ago. > doug > > , " G Hudson " <crudo20@> wrote: > > > > Is it still prevailing wisdom that Xiao Chai Hu Tang is > > contraindicated for patients undergoing interferon Tx? > > > > Geoff > > > > , " Eric Brand " > > <smilinglotus@> wrote: > > > > > > , " Alon Marcus " > > > <alonmarcus@> wrote: > > > > > > > > Misha > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 , " " wrote: > > Yes, Chai Hu raises the natural interferon levels and those on interferon therapy can > overdose. This was the cause of the many deaths in Japan a few years ago. > doug Did they narrow it down to the chai hu? I thought that only the formula xiao chai hu tang was linked to the interactions. Eric Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Yes, it was the Chai hu... doug -- In , " Eric Brand " <smilinglotus wrote: > > , " " > <taiqi@> wrote: > > > > Yes, Chai Hu raises the natural interferon levels and those on > interferon therapy can > > overdose. This was the cause of the many deaths in Japan a few years > ago. > > doug > > Did they narrow it down to the chai hu? I thought that only the > formula xiao chai hu tang was linked to the interactions. > > Eric > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Dan, Excellent article. Thanks for making the hot link. Bob Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 , " Eric Brand " <smilinglotus wrote: > > I'm looking for some good research articles on CM for the treatment of > side effects of interferon (in Hep C tx). \ subhuti at itm has a few articles in the start group http://www.itmonline.org/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2007 Report Share Posted March 13, 2007 Dan Do understand the article correctly, sho-saiko-to can cause Interstitial pneumonia in pt not doing interferon? - honsousa Tuesday, March 13, 2007 9:40 AM Re: Hep C and Interferon For those who are interested in clinical research on xiao chai hu tang and its reported interaction with interferon in Japan (it spells in Japanese as sho-saiko-to), I have published a review paper on Herbalgram on the Feburary issue (http://herbalgram.com/herbalgram/), thoroughly summerized over 50 medical journal publications. You can check this link and see if the journal is still having it free for the public: http://herbalgram.com/herbalgram/articleview.asp?a=3087 My paper is entitled: Sho-saiko-to, A Clinically Documented Herbal Preperation for Treating Chronic Liver Disease. You can also email me and request the PDF version of the paper. Dan Wen / Honso USA, Inc. , " " wrote: > > Yes, Chai Hu raises the natural interferon levels and those on interferon therapy can > overdose. This was the cause of the many deaths in Japan a few years ago. > doug > > , " G Hudson " <crudo20@> wrote: > > > > Is it still prevailing wisdom that Xiao Chai Hu Tang is > > contraindicated for patients undergoing interferon Tx? > > > > Geoff > > > > , " Eric Brand " > > <smilinglotus@> wrote: > > > > > > , " Alon Marcus " > > > <alonmarcus@> wrote: > > > > > > > > Misha > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 -Hi Folks: There is not any research done in the West that I know of. My research team (with hepatologists) have tried for more than ten years to have a research project funded of using Chinese medicine in HCV and five with interferon. We have a great protocol that works (anecdotally) with great support from the docs we work with but the studies are very expensive given the nature of the treatment (Western part that is). Anyway, Dr. Gish and I have rewritten the Western sections and have added a new chapter called The Optimum Interferon Protocol in the new revised edition of The Hepatitis C Help Book coming out in May 2007. It details all the side effect treatment and what to look for in creating a successful outcome with interferon. Yours Misha -- In , " Alon Marcus " <alonmarcus wrote: > Please share with all of us > Also, any info on how people are treating Pt with Hep C on interferon would be appreciated > > > > > > - > Eric Brand > > Monday, March 12, 2007 11:22 AM > Hep C and Interferon > > I'm looking for some good research articles on CM for the treatment of > side effects of interferon (in Hep C tx). Either acupuncture or > medicinal therapy would be fine, but preferably something that can > ultimately be traced to a primary source of some type (journal, etc). > I looked on Blue Poppy online and Pubmed, but no luck so far. > > Eric > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 Eric, Misha, Alon et al... rummaging through my shelves and hard-drives, I found this... 2: Phytomedicine. 2004 Jan;11(1):5-10. The effects of a herbal medicine (Mao-to) in patients with chronic hepatitis C after injection of IFN-beta. Kainuma M, Sakai S, Sekiya N, Mantani N, Ogata N, Shimada Y, Terasawa K. Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan. Kainuma We found that a herbal medicine (Mao-to) relieves the side effects of interferon (IFN)-beta and the combination therapy improves the biochemical response rate. However, the exact mechanism by which Mao-to is effective remains to be established. We conducted a controlled trial to clarify the effects of Mao-to. The study was carried out in 18 patients with chronic hepatitis C, and we examined subjective symptoms, body temperature and cytokines such as interleukin (IL)- beta, IL-1receptor antagonist (ra), IL-6 and TNF-alpha. Each patient received 6 million units of IFN-beta intravenously. Mao-to was given orally just before, just after, and 1 hour after IFN administration. The control study was carried out 6 months after the combination therapy of Mao-to and IFN-beta. The scores for general malaise, arthralgia and discomfort were significantly lower in the combination group than in control group. Body temperature did not significantly differ between the two groups. Plasma IL-6 level and IL-1ra were significantly elevated in the combination group compared to control (P = 0.0057 and 0.0003, respectively). Mao-to did not affect plasma concentrations of IL-1beta and TNF- alpha. We considered the increment of IL-1ra caused by Mao-to is to be one of the key factors involved in reducing the flu-like symptoms accompanying IFN- beta and improving the biochemical response rate. PMID: 14971716 [PubMed - in process] , " Misha Cohen " <TCMPaths wrote: > > -Hi Folks: > There is not any research done in the West that I know of. > My research team (with hepatologists) have tried for more than ten years to have a > research project funded of using Chinese medicine in HCV and five with interferon. We > have a great protocol that works (anecdotally) with great support from the docs we work > with but the studies are very expensive given the nature of the treatment (Western part > that is). > Anyway, Dr. Gish and I have rewritten the Western sections and have added a new chapter > called The Optimum Interferon Protocol in the new revised edition of The Hepatitis C Help > Book coming out in May 2007. It details all the side effect treatment and what to look for > in creating a successful outcome with interferon. > Yours Misha > > -- In , " Alon Marcus " <alonmarcus@> wrote: > > Please share with all of us > > Also, any info on how people are treating Pt with Hep C on interferon would be > appreciated > > > > > > > > > > > > - > > Eric Brand > > > > Monday, March 12, 2007 11:22 AM > > Hep C and Interferon > > > > I'm looking for some good research articles on CM for the treatment of > > side effects of interferon (in Hep C tx). Either acupuncture or > > medicinal therapy would be fine, but preferably something that can > > ultimately be traced to a primary source of some type (journal, etc). > > I looked on Blue Poppy online and Pubmed, but no luck so far. > > > > Eric > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 I've uploaded the full Pine Street article to the Files Section folder Hepatitis. It is about HBV, a slightly different animal. I have forgotten if I purchased this document or was available free. Support Pine Street if it is a for-pay article. doug http://www.positivehealth.com/permit/Updates/rudherb3.htm Issue 85 MCCULLOCH and colleagues, Pine Street Clinic, San Anselmo, CA, USA, analyze Chinese herbal medicine and interferon in the treatment of chronic hepatitis B. Background: This meta-analysis was performed in order to evaluate the effectiveness of Chinese herbal medicine alone or in combination with interferon-alpha in treating chronic hepatitis B. Methods: TCMLARS, AMED, CISCOM, EMBASE, MEDLINE,and Cochrane Collaboration databases were searched and the articles? bibliographies were handsearched. Results: Chinese herbal medicine significantly reduced sero-reversion of HbsAg and was equivalent to interferon-alpha in sero-reversion of HbeAg and Hepatitis B virus DNA. Chinese herbal medicine combined with interferon-alpha significantly increased seor- reversion of HBsAg, HBeAg, and viral DNA. The Chinese herb active component bufotoxin combined with Interferon-alpha significantly increased HbeAg and viral DNA sero-reversion. The Chinese herb active component kurorinone was equivalent to interferon-alpha in sero-reversion of HbeAg and viral DNA. Conclusions: Although the quality of existing studies is poor, the data nevertheless suggest that further studies of Chinese herbal medicine and interferon in chronic hepatitis B infection are justified. McCulloch M, Broffman M, Gao J, Colford JMJr. Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: a meta-analysis of randomized. controlled trials. American Journal of Public Health 91 (10): 1619-1628, Oct 2002. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 Does anyone have a good treatment for the swelling, itching, pain and redness that develops at the interferon injection sites? Thanks, Sean Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 I don't want to hijack the thread here... but would this interaction with interferon also apply to MS patients getting interferon? Geoff Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2007 Report Share Posted March 14, 2007 Thanks so much to everyone for the thoughtful Hep C/interferon responses! There is some relatively interesting reading on pubmed for this issue where the herbs are concerned, but still there are only a handful of articles that address the issue of interaction directly. Not really much out there in the way of acupuncture research, but that is no great surprise. Interestingly, one of the relevant articles (on Pubmed and also summarized by Doug on the list) cites the use of Mao-to, which is the Japanese name for Ma Huang Tang. No doubt few of us would have spontaneously thought of using ma huang tang in such a situation! Eric Quote Link to comment Share on other sites More sharing options...
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