Herbal Medicine abstracts on Medline

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Hi All,

 

My notes (from Chinese WWW) on some Chinese fornulas, mentioned

below are:

(a) NAOMAITONG KOUFUYE (Brain Vessels Opening Oral Liquid) is a

patented CHM for oral use in acute ischaemic stroke; FORMULA CLASS:

Quicken Xue & Move Xueyu; Rectify Xue For Non-Cold Patterns;

INGREDIENTS: Dahuang & Shizhi [main drugs to Open Organs & Attack

Below (Tongfu Gongxia), Quicken Xue & Resolve Xueyu]; Sanqi [special Hb

to Quicken Xue, Resolve Xueyu & also Haemostat]; Gualou, Shichangpu &

Chuanxiong [Clear Heat & Resolve Phlegm, Quicken Xue & Open Portals];

Zhishi, Houpo (Chuanpo) & Gegen [Envoys (Zuoshi) to Transport & Transfer

(Shuzhuan) oxygen (Daqi), Ascend Clear (Shengqing) & Descend Turbid

(Jiangzhuo) & Recover Qi Mechanism (Tiaoli Qiji)], etc; FORMULA

ACTIONS: Quicken Xue (Huoxue), Resolve Xueyu (Huayu), Open Vessels

(Tongmai), Open Organs (Tongfu), Rectify Qi (Tiaoqi), Clear Heat (Qingre),

Purge Heat (Xiere), Resolve Phlegm (Huatan) & Open Portals (Kaiqiao);

overall formula acts as Antithrombus to Aid brain Fx; Reduce cerebral

oedema (Xiao Naoshuizhong), reduce brain capillary leakage (permeability),

reduce brain-cell toxicity (Naoxibao Duxing); CLINICAL USES: Aid brain Fx

& Tx acute ischemic stroke (Jixing Quexuexing Zhongfeng) dt thrombus, w

cerebral oedema, capillary leakage, threatened brain-cell death / toxicity;

(b) NAOMAITONG ZHUSHE YE (Brain Vessels Opening Injection Liquid) is

an injectable form that combines w (Lianhe) conventional thrombolysis

(Rongshuan, Dissolve Plug) therapy to correct (Dui) thrombo-embolic

(Xueshuan Shuansexing) brain ischaemia (Naoquexue); it can Tx ischaemic

cerebral vascular disease; resist calcium overload; Rectify imbalance

between thromboxane (TXA) & prostaglandin (PG); Antioxidant to block lipid

peroxidation mediated by free radicals, thus protect brain / cerebrum

© ZIBU PIYIN FANGYAO (Tone SP Yin Prescription (from Dalian Medical

Group medicine company, China)); INGREDIENTS: Renshen, Shanyao,

Baishao, Danshen, Shichangpu, Yuanzhi; FORMULA ACTIONS: Tone SP,

esp SP Yin; Antioxidant; Stabilise Cell Membranes; improve mitochondrial

membrane Na +-K +-ATPase, Ca 2 +-Mg 2 +-ATPase activity; Nourish

Brain; Neuroprotective; Antistress; Aid Memory; Antiageing; prevent & cure

clinical brain aging and senile (Laonianxing) encephalopathy (Naobing

Titongzi); CLINICAL USES: prevent & Tx SP Xu, esp SP Yinxu w S & Ss of

ageing / senility, incl failing brain Fxs, failing to cope w stress, amnesia &

senile encephalopathy / dementia~ early; NOTE: Body aging (senile wear &

tear) relates closely to KI Xu, SP Xu, Xueyu; SP Xu obstructs (Zhang'ia)

body's (Jiti) energy metabolism (Nengliang Daixie); formula's antioxidant and

membrane-protection actions ensure (Baozhang) energy-metabolic

(Nengliang Daixiede) smooth progress (Shunli Jinxing) & slows down

(Yanhuan) brain ageing (Nao Laohua)

YIQI TONGMAI KOUFUYE (Augment Qi & Open Vessels Oral Liquid)

 

INGREDIENTS: Chuanxiong, Danggui, Danshen, Yanhusuo, Huangqi,

Wuyao (Taiwu), etc;

 

ACTIONS: Augment Qi (Yiqi) , Quicken Xue (Huoxue), Resolve Xue Stag

(Huayu), Open Vessels (Tongmai), Warm & Stop Pain (Wentong Zhitong);

 

CLINICAL USES: prevent & cure (Fangzhi) acute (Jixing) myocardial

ischaemia (Xinji Quexue) in Chest Bi (Xiongbi), i.e. CHD (Guanxinbing) &

angina pectoris (Xinjiaotong) & chest oppression (Xiongmen) dt Qixu &

Yangxu, Qi Stag (Qizhi) & Xue Stag (Xueyu) w paralysis & blockage (Bizu)

of HT vessels (Xinmai), obstruction (Butong) w pain (Ze Tong);

 

DISCUSSION: CHD usually has Qi Stag, Xue Stag, Phlegm Turbidity

(Tanzhuo), Cold Congelation (Hanning), etc w paralysis & blockage of HT

vessels, obstruction w pain; location of CHD is primarily in HT & KI,

extending to affect SP; 90% of CHD cases have Benxu (Root Deficiency) w

Biaoshi (Exterior Excess) as basic cause; Qixu & Yangxu are prime factors

in Benxu; Xueyu & Phlegm Turbidity often appear in Exterior Excess; Benxu

+ Qixu occur in 63% of cases; Qixu + HT Qixu occurs in 74% of cases;

Yinxu & Yangxu are less important; Biaoshi + Xueyu & Qizhi occur in 85% of

cases; at only 15% of cases, Phlegm Turbidity is of minor importance; thus,

Qixu + Xueyu is most important pathogenic factor in CHD; thus Augment Qi,

Quicken Xue & Stop Pain (Yiqi Huoxue Zhitong) are main Tx principles in

CHD & angina; formula addresses all of these effectively & w minimal

adverse effects; Qixu + Xueyu, causing chest oppression are key features in

CHD angina; formula attacks & fixes both simultaneously (Gongbu Jianshi),

treating Root & Branch (Biaoben Tongzhi), acting to Mend & Negate

(Bu'erwu) obstruction & Stag Disease (Yongzhibing); Formula is effective &

safe to Tx Chest Bi (CHD w angina pectoris)

 

(e) YIQI TONGMAI TANG (Augment Qi & Open Vessels Dec)

INGREDIENTS: (see: Yiqi Tongmai Koufuye)

ACTIONS: (see: Yiqi Tongmai Koufuye)

CLINICAL USES: support (Peihe) WM (Xiyao) [oral isosorbide mononitrate

(Xiaosuan Yishanlizhi)] to ease (Huanjie) CHD w angina pectoris &

accompanying (Bansui) S & Ss (Zhengzhuang) & increase (Gaishan) HT

muscle (Xinji) supply of blood (Gongxue)

 

 

See these:

 

Shi X, Zhu XD, Wang HM. [Effect of supporting the healthy energy and

strengthening Pi principle of TCM combined with chemotherapy in treating

children with solid tumors] [Article in Chinese] Zhongguo Zhong Xi Yi Jie He

Za Zhi. 2007 Jun;27(6):542-5. Beijing Children's Hospital, Capital Medical

University, Beijing. shixue1254 OBJECTIVE: To study the clinical

validity in improving quality of life (QOL) of patients and alleviating adverse

reaction of chemotherapy in treating children with solid tumors by Chinese

herbal medicine for supporting healthy energy and strengthening Pi.

METHODS: A prospective cohort study was conducted in 60 children with

solid tumor in stage II-IV, who were assigned to two groups, 30 in each

group. All children received chemotherapy and those in the observed group

were given Chinese herbs according to syndrome differentiation additionally.

The conditions of the two groups were compared after 6-month treatment.

RESULTS: Compared with before treatment, the white blood cells (WBC),

hemoglobin (Hb), and platelet (PLT) all increased in the observed group

after treatment (P < 0.01, P < 0.01, P < 0.05), while in the control group, the

WBC and Hb have no significant difference (P > 0.05) and PLT decreased

(P < 0.05) after treatment. Comparison between the two groups, the clinical

symptom score in the observed group has significant difference after

treatment (P < 0.05). CONCLUSION: Chinese herbal medicine for

supporting healthy energy, strengthening Pi and supplementing qi-blood is

good for alleviating the adverse reaction and improving patients' peripheral

blood picture in children with solid tumor undergoing chemotherapy. PMID:

17633370 [PubMed - in process]

 

Liu JX, Li JS, Wang D, Su J, Guo XY, Sun J, Li N. [Effects of Naomaitong

and thrombolysis on injuries of lung and stomach in rats with cerebral

ischemia.] [Article in Chinese] Zhong Xi Yi Jie He Xue Bao. 2007

Jul;5(4):451-6. Department of Geriatrics, Henan College of Traditional

, Zhengzhou, Henan Province 450008, China; E-mail:

ljs8. Objective: To study the protective effects of Naomaitong, a

compound traditional Chinese herbal medicine, used together with

thrombolysis therapy, on injuries of the lung and stomach in rats with

cerebral ischemia.Methods: Rats were randomly divided into sham-operated

group, untreated group, urokinase group (thrombolysis group), Naomaitong

group, thrombolysis plus Naomaitong group. Cerebral ischemia was induced

in rats by autonomous blood blot and inserted nylon thread. Rats were

administrated with thrombolysis therapy through artery 3, 6 and 9 h after

cerebral ischemia respectively. Twenty-four hours after the administration,

mortality of the rats, and the brain and stomach hemorrhage ratios, as well

as the pathological changes of the brain, lung and stomach were observed,

and then cerebral infarct size (CIS) and lung water ratio (LWR) were

measured.Results: Compared with the sham-operated group, the rat

mortality, and the brain and stomach hemorrhage ratios increased, the CIS

enlarged, pathological changes of the brain, lung and stomach appeared

obvious, and the LWR increased. Naomaitong plus thrombolysis treatment

improved the changes above significantly. In the untreated rats with cerebral

ischemia, injuries of the brain, lung and stomach were aggravated, the CIS

enlarged and the LWR increased in the 9 h group as compared with those in

the 3 h group. In the thrombolysis plus Naomaitong group, the pathological

changes were improved, the CIS diminished and the LWR reduced.

Conclusions: Injuries of the lung and stomach can be caused by cerebral

ischemia, and the impairment was exacerbated following the prolongation of

the ischemia. Thrombolysis therapy can cause brain and stomach

hemorrhage. Thrombolysis therapy used early can perform protection

against the injuries. Naomaitong, used together with thrombolysis, can

reduce the mortalityìthe brain and stomach hemorrhage ratios, and perform

protective effects on the injuries of cerebral ischemia. PMID: 17631812

[PubMed - in process]

 

Zhang S, Song YQ, Yue W, Mao XR, Ju CX, Dong MJ, Zheng QL, Dai XH,

Li ZY, Wang SP. [Multicentric randomized double blinded clinical study of

Yiqi Tongmai Oral Liquid against angina pectoris in patients with coronary

heart disease.] [Article in Chinese] Zhong Xi Yi Jie He Xue Bao. 2007

Jul;5(4):383-91. Pharmacy Department, Medical College of Qingdao

University, Qingdao, Shandong Province 266021, China; E-mail:

dr_zhangshuo. Objective: To study the efficacy and safety of Yiqi

Tongmai Oral Liquid (YQTM), a traditional compound Chinese herbal

medicine, in treating angina pectoris in patients with coronary heart

disease.Methods: A multicentric, randomized, double blinded and paralleled

controlled trial was conducted on 110 patients in trial group treated with

YQTM, and 109 patients in control group treated with Shuxin Oral Liquid

(SX). Cure and effective rates in both groups were evaluated. Frequency

and duration of angina attack were counted and measured. Coronary

angiography (CAG), electrocardiogram (ECG) and flat exercise test were

taken in both groups. Blood lipid indexes, such as cholesterol (CH),

triglyceride (TG), low-density lipoprotein (LDL), high density lipoprotein

(HDL), were determined at pre- and post-treatment. The hemodynamic

indexes, such as whole blood viscosity (J2), high-shear reduced viscosity

(Eh), low-shear reduced viscosity (Ei), red cell aggregation index (Lb), red

cell rigidity index (Rh), fibrinogen (Fb), blood sedimentation rate (BSR) and

hematocrit (HCT), were determined at pre-and post-treatment. The indicated

scores of symptoms and signs of traditional Chinese medicine (TCM)

pattern, such as chest pain, chest constriction, breath shortness, palpitation,

fatigue, dim complexion, spontaneous perspiration and tongue proper,

tongue coating were evaluated in week 0, 1, 2, 3, 4 during the treatment

course. The safety indexes, such as body temperature, pulse, respiration

and blood pressure were observed. Routine tests of blood, urine and stool,

hepatic function test and renal function test were taken at pre- and post-

treatment. Results: There was no significant difference between the total

effective rate of the trial group and that of the control group, which were

91.82% and 85.32%, respectively (P>0.05). Trial groupos percentile of cure

rate is significantly higher than that of the control group (P<0.01). The

frequency and duration of angina attack, the positive ratio of CAG and flat

exercise test of both groups were lowered, while the effect of the trial group

on frequency and duration of angina attack was better. No significant

difference was found in ECG features between the two groups (P>0.05).

The levels of CH, TG and LDL of both groups were lowered significantly

(P<0.05). The effect of lowering CH, TG and LDL of the trial group was

stronger than that of the control group (P<0.05). The hemodynamic indexes,

such as J2, Eh, Ei, Lb, Rh, Fb, BSR and HCT were improved significantly in

both groups (P<0.05). The improvements of J2, Eh, Ei, Lb, Rh, Fb and SR in

the trial group were greater than those of control group (P<0.05). The TCM

symptoms and signs, such as chest pain, chest constriction, breath

shortness, palpitation, fatigue, dim complexion, spontaneous perspiration

were improved significantly in both groups (P<0.05). The improvements of

chest constriction, palpitation, fatigue and spontaneous perspiration in the

trial group were greater than those of the control group (P<0.05). The total

indicated score of TCM symptoms and signs was lowered more significantly

than that of the control group (P<0.01). No significant changes were found at

pre- and post-treatment in safety indexes, such as routine tests for blood,

urine and stool, hepatic function test and renal function test. There was no

significant difference in safety features of both groups (P>0.05). Conclusion:

Yiqi Tongmai Oral Liquid bears good therapeutic effect on angina pectoris

without adverse reaction, and is superior to Shuxin Oral Liquid. Yiqi Tongmai

Oral Liquid is a new effective and safe medicine for the treatment of angina

pectoris in patients with coronary heart disease. PMID: 17631800 [PubMed -

in process]

 

Gao D, Lin JM, Zheng LP. [Experimental study on effect of xuefu zhuyu

decoction on bone marrow hematopoietic stem cells of mice] [Article in

Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jun;27(6):527-30.

Fujian College of Traditional , Fuzhou. OBJECTIVE: To

investigate the effect of Xuefu Zhuyu Decoction (XFZYD) on the number,

phenotype, cell cycle and colony formation of bone marrow hematopoietic

stem cells (HSC) in mice. METHODS: Kunming mice were randomly divided

into 4 groups: the control group, the low- (3.25 g/kg), middle- (6.5 g/kg) and

high-dose (13.0 g/kg) XFZYD groups. After they were medicated by

gastrogavage respectively with saline or corresponding dose of XFZYD for 7

days, their bone marrow HSC were separated and counted. The phenotype

Sca and cell cycle of HSC were detected by flow cytometer, and the colony

formation was determined with semisolid methyl media culture. RESULTS:

No obvious difference in the number of mononuclear cell, suspended cell

and colony production was found among all the groups (P > 0.05); while the

expression of CD34 and Sca-1 increased in the low-dose XFZYD group, but

in the middle-dose XFZYD group increase only showed in Sca-1 expression.

CONCLUSION: XFZYD plays a role of removing blood stasis and promoting

regeneration through improving hematopoietic function by means of

increasing the number and enhancing the function of premature HSC. PMID:

17633366 [PubMed - in process]

 

Zhou F, Shen XH. [Effects of serum containing Yiqi Xiaoji Recipe on cell

line NKN-28 of gastric cancer.] [Article in Chinese]. Zhong Xi Yi Jie He Xue

Bao. 2007 Jul;5(4):442-4. Department of Traditional ,

Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai

200025, China; E-mail: meilixl. Objective: To explore the

effects of serum containing Yiqi Xiaoji Recipe (YQXJR), a compound

traditional Chinese herbal medicine for benefiting qi and removing

stagnation, on cell line NKN-28 of gastric cancer. Methods: The

experimental SD rats were taken as the provider of the animal serum, and

the serum was inactivated before the experiment. The serum was divided

into high-dose, medium-dose, low-dose and blank serum groups based on

whether the rats were given YQXJR and administration dosage. The

inhibition rate was regarded as the observational index.Results: The four

groups of serum all had inhibitory effect on the growth of NKN-28 cells

depending on the drug concentration. And there were significant differences

among the experimental groups. High-dose, medium-dose and low-dose

concentrations of serum all could inhibit the growth of NKN-28 cells with

positive relations with the concentration and function time.Conclusion:

YQXJR serum can inhibit the growth of NKN-28 cells depending on the drug

concentration and function time. PMID: 17631810 [PubMed - in process]

 

Lee S, Kim DH, Jung JW, Oh JH, Park HJ, Park C, Huh Y, Cheong JH, Oh

TH, Ryu JH. Schizandra chinensis and Scutellaria baicalensis counter stress

behaviors in mice. Phytother Res. 2007 Jul 18; [Epub ahead of print]

Department of Oriental Pharmaceutical Science and East?West

Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee

University, 1 Hoeki?dong, Dongdeamoon?ku, Seoul 130?701, Korea. The

individual and combined antistress effects of the fruit of Schizandra

chinensis and the radix of Scutellaria baicalensis were evaluated using a

mouse acute stress model. Stress consisted of immobilization and electric

foot shocks over 5 days. Mice were treated with herbal extracts for 7 days

before exposing the animals to stress. Before each stressor presentation,

the mice were treated with each herbal extract. Reduced locomotor activity

and the percentage of time spent in the open arms of an elevated plus-maze

under stress were recovered by treatment with the extract containing equal

amounts of S. chinensis and S. baicalensis (CB11) at 200 and 400 mg/kg (p

< 0.05). The effects of CB11 were greater than the effects of S. chinensis or

S. baicalensis alone. CB11 treatment (100, 200 and 400 mg/kg) significantly

reduced serum corticosterone levels (p < 0.05). Spleen size and the serum

interleukin-2 level decreases induced by stress were prevented by CB11

(200 mg/kg) (p < 0.05). Taken together, these results suggest that S.

chinensis and S. baicalensis in equal amounts could be used to treat stress

disorders, in part, by preventing corticosterone and IL-2 level changes and

ameliorating stress-related behavior parameters. Copyright © 2007 John

Wiley & Sons, Ltd. PMID: 17639560 [PubMed - as supplied by publisher]

 

Friedman JA, Taylor SA, McDermott W, Alikhani P. Multifocal and Recurrent

Subarachnoid Hemorrhage Due to an Herbal Supplement Containing

Natural Coumarins. Neurocrit Care. 2007 Jul 17; [Epub ahead of print]

Department of Surgery, Neuroscience and Experimental Therapeutics,

Texas A and M Health Science Center College of Medicine, College Station,

TX, USA. INTRODUCTION: Over-the-counter herbal and alternative

medicines are classified as dietary supplements and, unlike drugs, are not

rigorously regulated by the United States Food and Drug Administration.

Their potential adverse effects are often poorly characterized. METHOD:

Red clover, dong quai, and Siberian ginseng are herbal compounds used for

treatment of perimenopausal symptoms such as hot flashes. These

compounds are known to contain coumarins, and thus carry the potential for

hemorrhagic complications; however, no cases of intracranial hemorrhage

have been reported. DISCUSSION: We report a 53-year-old woman with

spontaneous subarachnoid hemorrhage due to the use of an herbal

supplement containing red clover, dong quai, and Siberian ginseng. PMID:

17634840 [PubMed - as supplied by publisher]

 

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