Medline Herbal Abstracts

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See:

 

Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):232-5.Links [Comparision of

different interventional therapies for primary liver cancer] [Article in

Chinese]

Liu YM, Qin H, Wang CB, Fang XH, Ma QY. Congenital Heart Disease and

Peripheral Vascular Disease Center, First Hospital, Xi'an Jiaotong

University, Xi'an 710061, China. doctor-lym OBJECTIVE: To

investigate the efficacy of different interventional therapies for primary

hepatic cell cancer (HCC). METHODS: 1126 HCC patients before or after

hepatectomy were treated by different kinds of interventional therapies:

transcatheter arterial chemoembolization (TACE), TACE and radio-

frequency ablation (RFA), Chinese traditional medicine and biotherapy after

TACE or the transcatheter arterial infusion (TAI). The results of liver

function, alpha-fetoprotein, imaging, color-ultrasonography and survival rate

were reviewed. RESULTS: 874 patients were followed up for 2 to 63

months. The overall 1-, 3-, 5-year survival rate was 67.8% , 28.7% and

18.8%, respectively. The 1-, 3-, 5-year survival rate of patients who received

TACE before hepatectomy was 74.7%, 41.4% and 36.9% ; after

hepatectomy 78.9%, 40.4% and 37.5%, respectively. The response rate (

PR + NC) of TACE and RFA was 93.4%, and the 1-, 3-year survival rate was

74.5% and 36.8%, respectively, after TACE and RFA. The response rate

(PR + NC) of TACE was 83.2% with 1-, 3-, 5-year survival rate of 69.3%,

21.7%, 8.4% after TACE, respectively. The response rate (PR + NC) of TAI

was 27.5% with 1-, 2-year survival rate of 11. 6% and 0 after TAI. The Child

grade of liver function, color-ultrasonography and alpha-fetoprotein of TACE

+ RFA group, TACE and TAI were compared. There was no significant

difference between each above mentioned index among TACE, RFA or

TACE groups. CONCLUSION: Compared with other modalities,

transcatheter arterial chemoembolization (TACE) before or after

hepatectomy is more effective than other interventional therapies for primary

hepatocellular cancer, whereas, if combined with radiofrequency ablation

(TAI), it is much more effective than TACE alone. PMID: 17649645 [PubMed

- in process]

 

Prog Brain Res. 2007;162:525-46. Links Oxidative stress and ischemic

injuries in heat stroke. Chang CK, Chang CP, Liu SY, Lin MT. Department of

Surgery, Mackay Memorial Hospital, Taipei, Taiwan; Graduate Institute of

Injury Prevention and Control, Taipei Medical University and Municipal Wan-

Fan Hospital, Taipei, Taiwan. When rats were exposed to high

environmental temperature (e.g., 42 or 43 degrees C), hyperthermia,

hypotension, and cerebral ischemia and damage occurred during heat

stroke were associated with increased production of free radicals

(specifically hydroxyl radicals and superoxide anions), higher lipid

peroxidation, lower enzymatic antioxidant defenses, and higher enzymatic

pro-oxidants in the brain of heat stroke-affected rats. Pretreatment with

conventional hydroxyl radical scavengers (e.g., mannitol or alpha-

tocopherol) prevented increased production of hydroxyl radicals, increased

levels of lipid peroxidation, and ischemic neuronal damage in different brain

structures attenuated with heat stroke and increased subsequent survival

time. Heat shock preconditioning (a mild sublethal heat exposure for 15min)

or regular, daily exercise for at least 3 weeks, in addition to inducing

overproduction of heat shock protein 72 in multiple organs including brain,

significantly attenuated the heat stroke-induced hyperthermia, hypotension,

cerebral ischemia and damage, and overproduction of hydroxyl radicals and

lipid peroxidation. The precise function of heat shock protein 72 are

unknown, but there is considerable evidence that these proteins are

essential for survival at both normal and elevated temperatures. They also

play a critical role in the development of thermotolerance and protection

from oxidative damage associated with cerebral ischemia and energy

depletion during heat stroke. In addition, Shengmai San or magnolol

(Chinese herbal medicines) or hypervolemic hemodilution (produced by

intravenous infusion of 10% human albumin) is effective for prevention and

repair of ischemic and oxidative damage in the brain during heat stroke.

Thus, it appears that heat shock protein 72 preconditioning induced by prior

heat shock or regular exercise training, as well as pretreatment with

Shengmai San or magnolol is able to prevent the oxidative damage during

heat stroke. On the other hand, hypervolemic hemodilution, Shengmai San,

or magnolol is able to treat the oxidative damage after heat stroke onset.

PMID: 17645935 [PubMed - in process]

 

J Ethnopharmacol. 2007 Aug 15;113(1):15-34. Epub 2007 Jun 2. Links

Huperzine A from Huperzia species-An ethnopharmacolgical review. Ma X,

Tan C, Zhu D, Gang DR, Xiao P. State Key Laboratory of Drug Research,

Institute of Materia Medica, Shanghai Institutes for Biological Sciences,

Chinese Academy of Sciences, Shanghai 201203, PR China; Department of

Plant Sciences and BIO5 Institute, The University of Arizona, 303 Forbes

Building, Tucson, AZ 85721-0036, USA. Huperzine A (HupA), isolated

originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of

Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae

family, has attracted intense attention since its marked anticholinesterase

activity was discovered by Chinese scientists. Several members of the

Huperziaceae (Huperzia and Phlegmariurus species) have been used as

medicines in China for contusions, strains, swellings, schizophrenia,

myasthenia gravis and organophosphate poisoning. HupA has been

marketed in China as a new drug for Alzheimer's disease (AD) treatment

and its derivative ZT-1 is being developed as anti-AD new drug candidate

both in China and in Europe. A review of the chemistry, bioactivities,

toxicology, clinical trials and natural resources of HupA source plants is

presented. PMID: 17644292 [PubMed - as supplied by publisher]

 

 

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