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Br J Nutr. 2009 Jul;102(1):126-33. Epub 2009 Feb 10. Anti-inflammatory

effect of lycopene on carrageenan-induced paw oedema and hepatic

ischaemia-reperfusion in the rat. Bignotto L, Rocha J, Sepodes B, Eduardo-

Figueira M, Pinto R, Chaud M, de Carvalho J, Moreno H Jr, Mota-Filipe H.

Departamentos de Farmacologia, Universidade Estadual de Campinas, São

Paulo, SP, Brazil. The regular intake of tomatoes or its products has been

associated with a reduced risk of chronic diseases and these effects have

been mainly attributed to lycopene. Here, we evaluated the anti-

inflammatory properties of lycopene and its protective effects on organ injury

in two experimental models of inflammation. In order to study the effects of

lycopene in local inflammation, a carrageenan-induced paw oedema model

in rats was performed. Lycopene was administered as an acute (1, 10, 25 or

50 mg/kg, intraperitoneally, 15 min before carrageenan injection) and

chronic treatment (25 or 50 mg/kg per d, 14 d). Inflammation was assessed

by the measurement of paw volume increase after 6 h. Lycopene

significantly inhibited paw oedema formation at two doses (25 and 50

mg/kg) in both acute and repeated administration. The effect of lycopene on

liver inflammation was evaluated in a liver ischaemia-reperfusion (I/R)

model. Rats were subjected to 45 min of ischaemia of three-quarters of the

liver followed by 2 h of reperfusion. In this model, lycopene was

administered daily at two doses (25 and 50 mg/kg) during the 14 d that

preceded the experiments. Repeated administration of lycopene reduced

liver injury induced by I/R, as demonstrated by the reduction of the increase

in liver injury markers (aspartate aminotransferase, alanine

aminotransferase, lactate dehydrogenase and gamma-glutamyl transferase)

and attenuation of liver tissue lipoperoxidation was evidenced by a decrease

in malondialdehyde production. CONCLUSIONS: Lycopene had local anti-

inflammatory activity and also attenuated liver injury induced by I/R.

Lycopene administration may be useful in the pharmacological modulation

of inflammatory events. Publication Types: * Comparative Study PMID:

19203414 [PubMed - indexed for MEDLINE]

 

Drug Chem Toxicol. 2009;32(1):38-46. Investigation of biological activity of

polar extracts isolated from Phlomis crinita Cav ssp. mauritanica Munby.

Limem-Ben Amor I, Skandrani I, Boubaker J, Ben Sghaïer M, Neffati A,

Bhouri W, Bouhlel I, Chouchane N, Kilani S, Guedon E, Ghoul M, Ghedira

K, Chekir-Ghedira L. Laboratory of Cellular and Molecular Biology, Faculty

of Dental Medicine, Monastir, Tunisia. The lyophilized infusion, the

methanol, the ethyl acetate, and the total oligomer flavonoid (TOF)-enriched

extracts prepared from the dried leaves of Phlomis crinita Cav. ssp.

mauritanica Munby were investigated for the contents of flavonoids, tannins,

coumarines and steroids. Antibacterial activity was investigated toward five

bacterial strains. An inhibitory effect was observed against Staphyllococcus

aureus and Enterococcus feacalis, and the minimal inhibitory concentrations

ranged from 2.5 to 5 mg/mL of extract. The tested extracts exhibit an

important free radical scavenging activity toward the 1,1-diphenyl 2-

picrylhydrazyl (DPPH) free radical; with IC(50) values of 30.5, 6, 32, and

31.5 microg/mL, respectively, in the presence of lyophilized infusion, the

TOF, the methanol, and the ethyl acetate extracts. Genotoxic and

antigenotoxic properties of the different extracts were studied by using the

SOS chromotest with Escherichia coli PQ37. The lyophilized infusion and

TOF extracts obtained from P. crinita ssp. mauritanica showed no

genotoxicity, whereas methanol and ethyl acetate extracts are considered

as marginally genotoxic. On the other hand, we showed that each extract

inhibited the mutagenicity induced by aflatoxin B1 (AFB1) (10 microg/assay)

and nifuroxazide (NF) (10 microg/assay). The ethyl acetate extract showed

the strongest level of protection toward the genotoxicity induced by both

directly and indirectly genotoxic NF and AFB1. These tests proved that the

lyophilized infusion possesses an antiradical activity likewise, it showed no

genotoxic effect; that is why we choose this extract to assess its

antiulcerogenic activity by using an ethanol-induced ulcerogenesis model in

the rat. CONCLUSIONS: 300 mg/kg of a P. crinita ssp. mauritanica

lyophilized infusion was more effective than the reference compound,

cimetidine. Publication Types: * Comparative Study * Research Support,

Non-U.S. Gov't PMID: 19514937 [PubMed - indexed for MEDLINE]

 

Eur J Pharmacol. 2009 Mar 15;606(1-3):172-9. Epub 2009 Jan 10.

Green tea (-)-epigallocatechin-3-gallate down-regulates VASP expression

and inhibits breast cancer cell migration and invasion by attenuating Rac1

activity. Zhang Y, Han G, Fan B, Zhou Y, Zhou X, Wei L, Zhang J.

Department of Pathology and Pathophysiology, Hubei Provincial Key

Laboratory of Allergy and Immune-Related Diseases Centre for Medical

Research, Wuhan Univ, Wuhan, China. (-)-Epigallocatechin-3-gallate

(EGCG) is a polyphenolic compound from green tea that has been shown to

have anti-tumor activities such as inhibiting adhesion, migration, and

proliferation of tumor cells. However, the delicate mechanisms and signaling

pathways underlying the potential anticancer effects of EGCG in breast

cancer cells remain unclear. The goal of this study was to examine the

effects of EGCG on the migration and invasion of MCF-7 cells and to

identify the signaling pathway(s) underlying the cellular response to EGCG

exposure. In a concentration-dependent manner, EGCG decreased the

migratory and invasive potential of MCF-7 cells with a concomitant down-

regulation of vasodilator-stimulated phosphoprotein (VASP) expression and

Rac1 activity. Using specific siRNAs to block the expression of VASP and

Rac1 in MCF-7 cells that were previously treated with epidermal growth

factor (EGF), we demonstrated that the regulation of cell migration and

invasion was associated with Rac1 activity and VASP expression. In

addition, siRNA mediated knock-down of Rac1 decreased the amount of

VASP expression at the mRNA level while VASP specific siRNA revealed no

effect on the expression of Rac1 in MCF-7 cells. CONCLUSION: The

inhibitory effect of EGCG on MCF-7 cell migration and invasion may be

produced by a down regulation of VASP expression via the Rac1 pathway.

Publication Types: * Research Support, Non-U.S. Gov't PMID: 19171136

[PubMed - indexed for MEDLINE]

 

Int Arch Allergy Immunol. 2009;150(1):32-42. Epub 2009 Apr 2. Suppressive

effects of ginsan on the development of allergic reaction in murine asthmatic

model. Lim YJ, Na HS, Yun YS, Choi IS, Oh JS, Rhee JH, Cho BH, Lee HC.

Department of Microbiology, Chonnam National Univ Medical School, Brain

Korea 21 Project, Center for Biomedical Human Resources at Chonnam

National Univ, Gwangju 501-746, Republic of Korea. BACKGROUND:

Asthma is a major health problem and the morbidity and mortality caused by

asthma are on the rise. Corticosteroid therapies for asthma treatment

frequently induce many side effects. Therefore, the development of new

medicines that have both high efficacy and fewer side effects has been a

scientific challenge. Here we tested the effect of ginsan, a polysaccharide

derived from Panax ginseng, against allergic reaction in an ovalbumin

(OVA)-induced murine asthmatic model in comparison with dexamethasone,

and investigated its underlying mechanism. METHODS: To induce murine

asthma, mice were sensitized and challenged with OVA. Ginsan or

dexamethasone was administered by injection 3 times a week. Airway

hyperresponsiveness, airway inflammation and lung pathology were

assessed in order to evaluate the effect of ginsan against asthma.

RESULTS: Ginsan treatment reduced airway hyperresponsiveness,

remodeling and eosinophilia. These effects of ginsan were equivalent to

those of dexamethasone. Ginsan treatment decreased the IL-5 level in the

supernatant of cultured splenocytes, while IFN-gamma and serum IgE were

not altered. To elucidate the mechanism of ginsan, expression of

inflammation-related genes were screened. Interestingly, ginsan treatment

upregulated cyclooxygenase (COX)-1 and COX-2 mRNA, and expression of

their proteins in the lung were also increased. PGE(2) in the bronchoalveolar

lavage fluid was also increased by the ginsan treatment. Lastly, ginsan

inhibited the allergic reaction aggravated by COX inhibitor (indomethacin).

CONCLUSION: Ginsan has anti-asthmatic effects, which seem to be

partially mediated by enhancing the synthesis of COX gene products.

Copyright 2009 S. Karger AG, Basel. Publication Types: * Research

Support, Non-U.S. Gov't PMID: 19339800 [PubMed - indexed for MEDLINE]

 

Int Braz J Urol. 2009 Jul-Aug;35(4):396-405. Use of TCM in the

management of urinary stone disease. Miyaoka R, Monga M. Department of

Urologic Surgery, Univ of Minnesota, Minneapolis, Minnesota, USA.

OBJECTIVE: To assess the evidence-based literature supporting the use of

TCM Kampo herbal and AP in stone disease management. MATERIALS

AND METHODS: 4 of the most commonly used herbal components of

Kampo medicine in the treatment of stone disease are described according

to their in vitro and in vivo effects. We also reviewed the role of AP in

urologic clinical setting as well as its proposed mechanisms of action and

results. Medline database was assessed using isolated and conjugated key

words (, Kampo, Chinese Herbal, Calculi, Stone Disease,

Kidney, AP, Herbal Medicine). Articles were reviewed and summarized.

RESULTS: Herbal medicine has been proven to be free from side-effects

and therefore suitable for long term use therapy. Its antilithic beneficial

effects include increased urinary volume, increased magnesium excretion

(ZEXIE / TAKUSYA), inhibitory activity on calcium oxalate aggregation

(ZEXIE / TAKUSYA, WULING SAN & GUANGJINQIANCAO / DESMODIUM

STYRACIFOLIUM), inhibition of calcium oxalate nucleation and

hydroxyapatite internalization (WULING SAN). In contrast, AP, was effective

as a pre-treatment anxiolytic and analgesic during colic pain and

extracorporeal shock wave lithotripsy treatment, reducing the need for

complementary sedative drugs. CONCLUSION: TCM is promising as

regards its role in stone prevention. An effort must be made in order to

standardize study protocols to better assess AP results since each

procedure differs in regards to selected acupoints, electrostimulation

technique and adjunct anesthetics. Similarly, standardization of Kampo

formulations and acceptable clinical endpoints (imaging vs. symptomatic

events) is needed. Publication Types: * Research Support, Non-U.S. Gov't

PMID: 19719854 [PubMed - in process]

 

Int J Cardiol. 2009 Jun 26;135(2):254-5. Epub 2008 Sep 14.

Sulfotanshinone Sodium Injection could decrease fibrinogen level and

improve clinical outcomes in patients with unstable angina pectoris. Yan FF,

Liu YF, Liu Y, Zhao YX. We randomly divided 100 unstable angina pectoris

(UAP) patients into two groups: the trial group received a Danshen

metabolite, Sulfotanshinone Sodium Injection (SSI) 60 mg, combined with a

loading dose of 300 mg aspirin and a maintenance dose of 100 mg of

aspirin plus baseline therapy, and the control group received the same

doses of aspirin and baseline therapy. 94 patients completed treatment.

After 4 weeks' medication, the severity of angina pectoris improved in both

groups, with a significant improvement in total effective rate in the trial

group

but no difference in the total effective rate of improvement seen on ECG.

Compared with baseline level, FIB level after treatment decreased

significantly in both groups but to a greater extent in the trial group. Similar

changes in DD levels were observed in both groups. With a background of

aspirin and baseline therapy, SSI can significantly attenuate angina pectoris

attacks in patients with UAP which may be associated with the decreased

level of FIB. Publication Types: * Letter * Randomized Controlled Trial PMID:

18790543 [PubMed - indexed for MEDLINE]

 

J Altern Complement Med. 2009 Jun;15(6):639-44. Effectiveness, safety,

and tolerability of powdered NIGELLA SATIVA (kalonji) seed in capsules on

serum lipid levels, blood sugar, blood pressure, and body weight in adults:

results of a randomized, double-blind controlled trial. Qidwai W, Hamza HB,

Qureshi R, Gilani A. 1 Department of Family Medicine, Aga Khan Univ,

Stadium RoadP.O. Box 3500, Karachi 74800, Pakistan.

waris.qidwai OBJECTIVE: The seed extracts from NIGELLA

SATIVA is used by Unani physicians of traditional medicine (Hakims or

Tabibs) and Ayurvedic practitioners (Vaids) in the treatment of several

medical disorders including dyslipidemia, obesity, and hypertension. It is,

therefore, important to prove or disprove the effectiveness, safety, and

tolerability of powdered N. sativa (Kalonji) seed in capsules on serum lipid

levels, blood sugar, blood pressure, and body weight in adults. DESIGN:

The study design was a randomized, double-blind trial.

SETTINGS/LOCATION: Conducted at Aga Khan Univ Hospital, Karachi,

from February 2006 to January 2007. SUBJECTS: Half of the respondents

received powdered N. sativa (Kalonji) seed in capsule and the rest received

a placebo. INTERVENTION/OUTCOME: Baseline and after-intervention

variables recorded were the following: body-mass index, waist-hip ratio,

blood pressure, fasting blood sugar, serum lipids, serum alanine

aminotransferase, and serum creatinine. RESULTS: 123 patients were

recruited. 64 and 59 patients were randomized to the intervention and the

control arms, respectively. 39 patients in the intervention group and 34 in the

control group completed the study. Favorable impact of powdered N. sativa

(Kalonji) seed in capsule was noted on almost all variables, but results were

not statistically significant because of small sample size. CONCLUSIONS:

Favorable impact of powdered N. SATIVA (Kalonji) seed in capsule was

noted on almost all variables, but results were not statistically significant. A

larger study with adequate sample size is recommended. Publication Types:

* Randomized Controlled Trial * Research Support, Non-U.S. Gov't PMID:

19500003 [PubMed - indexed for MEDLINE]

 

J Am Coll Nutr. 2009 Feb;28(1):1-6. Parkinson's disease and tea: a

quantitative review. Barranco Quintana JL, Allam MF, Del Castillo AS,

Navajas RF. Department of Preventive Medicine and Public Health, Faculty

of Medicine, Univ of Cordoba, Avda. Menéndez Pidal, s/n Cordoba 14004,

SPAIN. fm2faahm. PURPOSE: To evaluate the risk of PD

associated with tea consumption. Material and METHODS: We reviewed all

observational studies that evaluated the association between PD risk and

tea consumption. Only, 12 studies were identified: 11 case-control and 1

cohort. These studies were carried out between 1981 and 2003. The studies

represented different populations from 3 continents; North America, Europe

and Asia. The 3 studies from Asia were case-control studies of Chinese

populations. RESULTS: There was a clear protective effect of tea

consumption in the pooled risk estimate [OR: 0.83 (95% confidence interval

0.74 to 0.92)] with 2215 cases and 145578 controls. However, the

homogeneity test was significant (p value of 0.008), denoting heterogeneity

across the pooled studies. Pooled analysis applying the random effect

model was OR: 0.81 with 95% confidence interval nearly overlapping unity

(95% confidence interval 0.67 to 0.98). Tea consumers versus non-

consumers in Chinese populations had pooled OR of 0.73 with 95%

confidence interval 0.60 to 0.90 (470 cases and 623 controls). The p value

of homogeneity test was 0.96, denoting homogeneity across the pooled 3

studies. CONCLUSION: Tea consumption can protect against PD and this

protective effect is clearer in Chinese populations. The low rate of tea

consumption among persons with PD should provide us many valuable

insights into the nature of the illness. Publication Types: * Review PMID:

19571153 [PubMed - indexed for MEDLINE]

 

J Ethnopharmacol. 2009 Aug 25. [Epub ahead of print] Anti-inflammatory,

anti-nociceptive, and anti-psychiatric effects by the rhizomes of ALPINIA

OFFICINARUM on complete Freund's adjuvant-induced arthritis in rats. Lee

J, Kim KA, Jeong S, Lee S, Park HJ, Kim NJ, Lim S. College of Pharmacy

and Research Institute of Pharmaceutical Sciences, Seoul National Univ,

Seoul 151-742, Korea. ETHNOPHARMACOLOGICAL RELEVANCE:

ALPINIA OFFICINARUM Hance (Zingiberaceae) is an annual plant. Its

rhizome has long been used as an anti-inflammatory, an analgesic, a

stomachic and a carminative in traditional medicine. Objective: The aim of

this study was to test the anti-inflammatory effects of A. OFFICINARUM Rz

on acute and chronic arthritis in SD rats. METHODS: A. OFFICINARUM Rz

were extracted by refluxing using 80% ethanol. The fractions were prepared

by the fractionation of ethyl acetate (EtOAc), n-butanol, and water. This

extract was administrated to rats by peroral injection. Acute arthritis was

induced by a subcutaneous injection of carrageenan into the hind paw of SD

rats. Chronic arthritis was stimulated by a subcutaneous injection of

complete Freund's adjuvant (CFA) into the hind paw of SD rats. The paw

volume was measured using a plethysmometer, thermal hyperalgesia was

tested using a thermal plantar tester, hyperalgesia was evaluated by ankle

flexion evoked vocalizations, and the expression of c-Fos in the brain

hippocampus was measured with the avidin-biotin-peroxidase technique.

Nitric oxide (NO) production was evaluated on nitrite by a Griess assay in

lipopolysaccharide (LPS) induced murine macrophage RAW 264.7 cells.

RESULTS: An 80% ethanolic extract showed acute anti-inflammatory

activity that it reduced the edema volume in carrageenan-stimulated arthritis

and inhibited NO generation in LPS-induced RAW 264.7 cells. In addition,

this extract showed chronic anti-rheumatic and analgesic activities by

suppressing the swelling volume, by recovering the paw withdrawal latency,

and by inhibiting the flexion scores in CFA-induced arthritis. Particularly,

this

medicine had potent meaningful effects on the second signal of the left hind

paw in the form of an immunological reaction compared to its effects on the

first signal in the right hind paw after the CFA treatment. This also shows an

anti-psychiatric effect through control of the expression of the c-Fos protein

of the brain hippocampus in CFA-stimulated arthritis. On the other hand,

each fraction showed acute anti-inflammatory effects; the action of the

EtOAc fraction may have resulted from the suppression of NO production.

CONCLUSIONS: A. OFFICINARUM Rz may be viable therapeutic or

preventive candidates for the treatment of acute and chronic arthritis. PMID:

19715749 [PubMed - as supplied by publisher]

 

Saudi Med J. 2009 Jun;30(6):750-4. HYPERICUM PERFORATUM extracts

healed gastric lesions induced by hypothermic restraint stress in Wistar rats.

Cayci MK, Dayioglu H. Department of Biology, Faculty of Science and Arts,

Dumlupinar Univ, Kutahya, Turkey. kcayci OBJECTIVE:

To investigate the healing effects of HYPERICUM PERFORATUM (HP) on

gastric mucosal damage induced by hypothermic restraint stress (HRS.

METHODS: Sixty Wistar breed rats of 200-250 gm were used in this study

carried out at the Biology Department of Dumlupinar Univ, Kutahya, Turkey

in 2006. The animals were divided into 6 groups, 2 of which were controls.

The HRS were induced by strapping the rats on a wooden plank and

keeping them for 3 hours at 4 degrees Celsius after a starvation period of 36

hours. After HRS, 25, 50, and 100 mg/kg/day HYPERICUM PERFORATUM

extracts (HPEs) were orally administrated to the 3 groups during the 3-day

treatment. Fifty mg/kg ranitidine was administered everyday as

subcutaneous injection to a group selected as a positive control. At the end

of treatment, lesions in the stomach were evaluated macroscopically and

microscopically. RESULTS: Macroscopic analyses showed that treatment

with HPEs 25, 50, and 100 mg/kg/day significantly healed lesions compared

to control groups by 65, 95, and 75% (p=0.001). Treatment with ranitidine

also healed ulcers significantly compared with the control groups.

Histopathologic analyses indicated that 50 mg/kg/day HP produced the most

significant effect. CONCLUSION: Moderate doses of HP produced

significant healing of HRS induced gastric ulcer in rats. The present study

indicated that HPEs have therapeutic potential for the control of ulcers.

PMID: 19526154 [PubMed - indexed for MEDLINE]

 

Zhong Yao Cai. 2009 Jan;32(1):73-8. [Effects of REALGAR and prescription

containing REALGAR on stress response proteins, inflammatory mediators

and complements in fever rat models] [Article in Chinese] Tang YS, Wang

NS, Zhang YQ, Ye SM, Ou WP. Institute of Clinical Pharmacology,

Guangzhou Univ of , Guangzhou 510405, China.

tangyishan2005 OBJECTIVE: To explore the

pharmacological mechanism of REALGAR by the way of studying the

effects of REALGAR and the prescription containing REALGAR named

Niuhuang Jiedu Tablet on stress response proteins (heat shock protein 70,

HSP70 and heme oxygenase-1, HO-1), inflammatory cytokines (IL-1beta,

IL-6 and TNF-alpha), activities of nitric oxide synthetase (NOS) and its

isoenzyme (inducible nitric oxide synthetase, iNOS), and complements C3,

CA under pathologic status (fever model). METHODS: SD rats were

randomly divided into four groups, 15 rats in each: untreated normal group,

fever model group, REALGAR (90 mg/kg) group and Niuhuang Jiedu Tablet

(NJT, 1.404 g/kg) group. Each group was divided into three subgroups (5

rats/subgroup). Blood samples of the rats in subgroups were collected at 1

h, 2 h and 4 h after administration, respectively. ELISA method was used to

determine HSP70, IL-1beta, IL-6, and TNF-alpha levels in serum. Dual

wavelength spectrophotometry was used to determine activity of HO-1 in

serum. Spectrophotometry was used to test activities of nitric oxide

synthetase (NOS) and its isoenzyme (inducible nitric oxide synthetase,

iNOS) in serum. Immunonephelometery method was used to test

complements C3, C4 in serum. RESULTS: REALGAR and NJT significantly

increased the level of HSP70 in rat serum as compared with the fever model

group. REALGAR and NJT significantly enhanced the activity of HO-1 in rat

serum as compared with the fever model group. The increase ranges of

HO-1 activities at different time post administration changed with the arsenic

concentration in rat serum. REALGAR and NJT significantly decreased the

level of IL-1beta in rat serum as compared with fever model group, and the

level of IL-lbeta recovered normaly at 4 h after administration. NJT

significantly inhibited activities of NOS and iNOS in rat serum as compared

with the fever model group at 2 h after administration. CONCLUSION:

REALGAR as contained in certain prescriptions, at certain specific levels,

assists in removal of internal toxins by inducing stress protein (HSP70, HO-

1) to improve the positive stress level in the body and inhibiting some over-

releasing inflammatory mediators (IL-1beta) to reduce the inflammatory

reactions under pathologic status. Publication Types: * English Abstract *

Research Support, Non-U.S. Gov't PMID: 19445126 [PubMed - indexed for

MEDLINE]

 

Zhong Yao Cai. 2009 Jan;32(1):97-9. [Effects of GERANIUM SIBIRUM

extracts on liver metastases in nude mice with colonic cancer] [Article in

Chinese] Huang GD, You Y, Huang YH, Tang LJ, Yang ZF, Xu L, Huang

DF, Xiao MZ. The First Affiliated Hospital of Nanchang Univ, Nanchang

330006, China. OBJECTIVE: To establish nude mice models with the liver

metastases of colonic adenocarcinoma and study the effects of GERANIUM

SIBIRUM (LAOGUANCAO) extracts on them. METHODS: Nude mice liver

metastases model of colonic cancer was established with human colonic

cancer cells line(Ls 174t) inoculated into mice spleen. 36 nude mice were

randomly divided into 3 groups, containing control group, GERANIUM

SIBIRUM extracts group and hydroxycamptothecine group. The weight and

size of the mice and growth of the carcinoma were recorded. All specimens

were examined histologically. pS2 in blood in nude mice with liver

metastasis of colonic carcinoma was detected with nested RT-PCR.

RESULTS: The incidence of liver metastasis was 100% in this intrasplenic

injection model. The pathological results showed that tumour cells of liver

metastases were poorly differentiated human colonic adenocarcinoma. In

GERANIUM SIBIRUM extracts group, the tumor number and the weight of

liver metastases were significantly lower than those in

hydroxycamptothecine group (p<.05). Using semiquantitative examination,in

GERANIUM SIBIRUM extracts group,the relative value of pS2 expression in

blood was significantly higher than that in hydroxycamptothecine group

(p<.05). CONCLUSION: GERANIUM SIBIRUM extracts can effectively

inhibit the occurrence of liver metastases carcinoma and decrease the

positive expression of pS2, it also has better effect than

hydroxycamptothecine so that GERANIUM SIBIRUM extracts may become

the potential therapeutic strategy for liver metatstases of colonic cancer.

Publication Types: * English Abstract PMID: 19445132 [PubMed - indexed

for MEDLINE]

 

Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Mar;8(2):169-71. [Effects of

CHANSU INJECTION on transplanting-tumor models S180 in mice and

human colon cancer HT-29 in nude mice] [Article in Chinese] Yang ZH,

Liang YJ, Guo JW, Pan JQ, Ding Y, Li GN. Department of General Surgery,

Guangzhou Hospital of TCM, Guangzhou 510130, China.

huayang OBJECTIVE: To study the antitumor effects of

CHANSU INJECTION on transplanting- tumor of S(180) in mice and human

colon cancer HT-29 in nude mice. METHODS: Using transplanting- tumor

models of S(180) in mice and human colon cancer HT-29 in nude mice,the

tumor inhibitive ratio(IR) of CHANSU INJECTION was determined and

apoptosis was microscopically observed. RESULTS: Compared with tumor-

negative control groups, IR at different dosage of CHANSU in models of

S(180) and HT-29 was 19.1% - 38.2% and 9.5% - 15.8% respectively,there

was a dose-dependent relationship in models of S (180) (P< 0.05) and HT-

29 (P> 0.05). The tumor growth was markedly inhibited by

cyclophosphamide (CTX) in model of S(180) with IR of 70.7% and in model

of HT-29 with IR of 67.1%, compared with control groups, both P< 0.01;

apoptosis induced by CTX was markedly observed by in microscope

examination. No significant side effects were shown in the study group.

CONCLUSIONS: CHANSU INJECTION can significantly inhibit tumor

growth in model of S(180), but not in model of HT- 29. Different type of

tumor has different drug-sensitivity. Publication Types: * English Abstract

PMID: 16155834 [PubMed - indexed for MEDLINE]

 

Best regards,