Avoid Plastics !!! Human placenta cells die after BPA exposure - hormesis

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Teresa Binstock <binstockTue, Feb 2, 2010 at 6:58 AM[EF!] !!! Human placenta cells die after BPA exposure - hormesis

EarthFirstAlert- to receive more like thisHuman placenta cells die after BPA exposure.

<http://www.environmentalhealthnews.org/ehs/newscience/human-placental-cells-die-after-bpa-exposure/>

 

 

   * 2 February 2010

 

     Exposure to very low concentrations of the plasticizer bisphenol A

     (BPA) causes cellular damage and death in cultured human placenta

     cells, researchers report. The doses used for this study are

     similar to blood levels found in pregnant women. Particularly

     concerning was the observation that effects were most pronounced

     at the lowest - rather than the highest - concentrations of BPA.

 

   *

 

     more...

     <http://www.environmentalhealthnews.org/ehs/newscience/human-placental-cells-die-after-bpa-exposure/>

 

 

 

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*/Toxic effects of low doses of Bisphenol-A on human placental cells/*

 

Nora Benachoura and Aziz Aris

Toxicology and Applied Pharmacology Volume 241, Issue 3, 15 December

2009, Pages 322-328

$ http://tinyurl.com/y9wqhn5

 

Humans are exposed daily to a great number of xenobiotics and their

metabolites present as pollutants. Bisphenol-A (BPA) is extensively used

in a broad range of products including baby bottles, food-storage

containers, medical equipment, and consumer electronics. Thus, BPA is

the most common monomer for polycarbonates intended for food contact.

Levels of this industrial product are found in maternal blood, amniotic

fluid, follicular fluid, placental tissue, umbilical cord blood, and

maternal urine. In this study, we investigated toxic effects of BPA

concentrations close to levels found in serum of pregnant women on human

cytotrophoblasts (CTB). These cells were isolated from fresh placentas

and exposed to BPA for 24 h. Our results showed that very low doses of

BPA induce apoptosis (2 to 3 times) as assessed using M30 antibody

immunofluorescent detection, and necrosis (1.3 to 1.7 times) as assessed

through the cytosolic Adenylate Kinase (AK) activity after cell membrane

damage. We also showed that BPA increased significantly the

tumor-necrosis factor alpha (TNF-?) gene expression and protein

excretion as measured by real-time RT-PCR and ELISA luminescent test,

respectively. Moreover, we observed that induction of AK activation and

TNF-? gene expression require lower levels of BPA than apoptosis or

TNF-? protein excretion. Our findings suggest that exposure of placental

cells to low doses of BPA may cause detrimental effects, leading /in

vivo/ to adverse pregnancy outcomes such as preeclampsia, intrauterine

growth restriction, prematurity and pregnancy loss.