Molecule Found in Meat, Milk and Tumors

[Guest guest]

Molecule Found in Meat, Milk and Tumors - Study

Mon Sep 29, 5:22 PM ET

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By Maggie Fox, Health and Science Correspondent

 

WASHINGTON (Reuters) - A non-human molecule found in red meat and milk makes

its way into the human system when eaten -- and seems to build up especially

in tumors, U.S. researchers reported on Monday.

 

 

 

 

The compound, called sialic acid, is found on the surfaces of animal cells

but is not found in people, and may be one reason why animal-to-human organ and

tissue transplants do not work well. Animals have a version called Neu5Gc,

while humans carry Neu5Ac.

 

 

 

But researchers at the University of California San Diego found it does show

up in the human body, and showed it can be absorbed from eating red meat and

milk.

 

 

 

They also showed that the body produces an immune response against the

molecule.

 

 

 

Dr. Ajit Varki and colleagues, reporting in the Proceedings of the National

Academy of Sciences (<A

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to make any

recommendations based on their findings.

 

 

 

" Of course, there are already existing recommendations that people should not

consume too much food containing saturated fats, such as dairy products and

red meats, " Varki said in a statement.

 

 

 

" The highest amount (of Neu5Gc) was found in lamb, pork, and beef (so-called

'red meat'), " the researchers wrote. Levels were very low or undetectable in

poultry and fish, vegetables and hen's eggs.

 

 

 

Varki, who is not a vegetarian, noted that many studies have linked a diet

rich in meat and milk with cancer, heart disease and other diseases.

 

 

 

AUTOIMMUNE DISEASE

 

 

 

" The small amounts of Neu5Gc in normal tissues also raise the possibility

that anti-Neu5Gc antibodies are involved in autoimmunity, " the researchers said.

 

 

 

Autoimmune disease occur when the body mistakenly attacks healthy tissue and

include type-1 or juvenile diabetes and some types of arthritis. " In this

regard, it is interesting that vegetarian diet has been suggested to improve

rheumatoid arthritis, " they wrote.

 

 

 

But much research has focused on the fat content of animal fat or byproducts

of cooking meat as the cause of disease.

 

 

 

Varki's collaborator Dr. Elaine Muchmore developed an antibody -- an immune

system targeting protein -- that would hook onto Neu5Gc. The team found Neu5Gc

in human tumor samples and to a much lower degree in healthy tissue.

 

 

 

More tests showed that most people had made their own antibodies that

recognized Neu5Gc, and thus could potentially initiate an inflammatory immune

response.

 

 

 

Varki and two colleagues drank Neu5Gc purified from pork sources, and the

molecule showed up in their urine, blood, hair and saliva.

 

 

 

" We need to find out if there is any association between the presence of

Neu5Gc and/or the anti-Neu5Gc antibodies with any disease, " Varki said. " This

will

require large-scale population studies. "

 

 

 

In some cases the human immune response was similar to that seen when people

are exposed to another animal molecule, this one a cell surface molecule

called alpha galactose.

 

 

 

 

 

 

 

 

Varki noted that the molecule is almost certainly not immediately toxic to

people.

 

" Meat eating has certainly been a feature of human ancestors for many

hundreds of thousands of years, " he said.

 

" Thus, it is indeed possible that humans have developed some kind of

tolerance or indifference to Neu5Gc. However, most humans are continuing to make

antibodies against Neu5Gc. "

 

It could be that the damage only builds up over years -- and that as people

live longer, the consequences make themselves felt.

 

" However, we are now living longer and the question arises whether the

gradual accumulation of Neu5Gc and the simultaneous presence of antibodies

against

could be involved in some diseases of later life, " he said.

 

 

 

 

[Guest guest]

This is really interesting - it doesn't seem to have had much coverage on the television news though. Maybe they don't want it to be widely known.

 

Jo

 

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