BIG NEWS! USA Today: Three U.S. agencies aim to end animal testing

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This is truly UNBELIEVABLE. I was an editor at NIH just over a year ago and was one of two people who persuaded them to use cage-free eggs in their dining facilities. But I never thought this would happen in a million years. NIH and TWO OTHER agencies are going to look for alternatives to animal testing. WOW...and WOW! I don't think I've ever received such great news. ** Please buy products that don't use animal testing or animal byproducts! ** Article: http://www.usatoday.com/tech/science/2008-02-14-animal-tests_N.htm Three U.S. agencies aim to end animal testing Enlarge AFP A Chinese researcher injects a monkey with an experimental solution at a laboratory in Guangzhou, China. Three U.S. agencies have signed a "Memorandum of Understanding" to begin developing new methods besides animal testing. By Elizabeth Weise, USA TODAY An ambitious program announced today by a coalition of government agencies could lead to the end of animal testing to evaluate the safety of new chemicals and drugs. Three agencies — the Environmental Protection Agency, the National Toxicology Program and the National Institutes of Health — have signed a "Memorandum of Understanding" to begin developing the new methods. The collaboration is described in a paper in today's edition of the journal Science. The agreement is a

"milestone" says Martin Stephens of the Humane Society of the United States. "We believe this is the beginning of the end for animal testing. We think the (conversion) process will take about 10 years." The agencies acknowledge that full implementation of the shift in toxicity testing could take years because it will require scientific validation of the new approaches. Using human cells grown in test tubes and computer-driven testing machines, the scientists will eventually examine potentially toxic compounds in the lab rather than injecting them into mice, rats and rabbits and waiting to see if the animals die. The EPA has already begun evaluating 300 chemicals using the new methods. The first phase should be finished this year, says Robert Kavlok, director of the National Center for Computational Toxicology. Thousands of chemicals can be tested at one time in this way, a great advance over slow, expensive animal testing. It's done in a 3-by-5-inch glass tray with 1,536 tiny wells, each a fraction of a millimeter across, says Christopher Austin, director of NIH's Chemical Genomics Center. A few hundred human cells grown in a test tube go into each well. Then, guided by a computer, the testing machine drips a different chemical into each well. After some time has passed, the machine shines a laser through each well to see how many cells remain. A computer analyzes the toxicity of each compound based on how the cells react. For comparison, it's taken the EPA 30 years to rigorously test 2,500 potentially toxic compounds, says Elias Zerhouni, director of the National Institutes of Health. All the

data produced will be put into a public database. "We think it is very important for the entire public worldwide to have access to these very precious experimental results," says Kavlock. It's the fruit of work begun in 2005 by EPA and the National Toxicological Program to speed up toxicological testing. That resulted in a report by the National Research Council last year laying out how it might be done. To convert from animal to lab testing, the federal agencies will start with compounds previously tested on animals to confirm that the cell-based tests are accurate, says Francis Collins, director of the National Human Genome Research Institute. This won't mean that animal testing will disappear overnight, but it signals the beginning of the end, says

Zerhouni. Two greyhounds starved & dumped in New England. Go to www.greyhound.org/ and ATTEND next hearing March 3, Waltham, MA.