Childhood Soy Intake and Breast Cancer Risk in Asian American Women.

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

 

Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover RN,

Ziegler RG.

 

Clinical Genetics Branch and Epidemiology and Biostatistics Program, Division of

Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland;

University of Southern California School of Medicine, Los Angeles, California;

Epidemiology Program, University of Hawaii, Honolulu, Hawaii; and Northern

California Cancer Center, Fremont, California.

 

INTRODUCTION: Historically, breast cancer incidence has been substantially

higher in the United States than in Asia. When Asian women migrate to the United

States, their breast cancer risk increases over several generations and

approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be

responsible.METHODS: In this population-based case-control study of breast

cancer among women of Chinese, Japanese, and Filipino descent, ages 20 to 55

years, and living in San Francisco-Oakland (California), Los Angeles

(California) and Oahu (Hawaii), we interviewed 597 cases (70% of those eligible)

and 966 controls (75%) about adolescent and adult diet and cultural practices.

For subjects with mothers living in the United States (39% of participants), we

interviewed mothers of 99 cases (43% of eligible) and 156 controls (40%) about

the daughter's childhood exposures. Seventy-three percent of study participants

were premenopausal at diagnosis.RESULTS: Comparing highest with lowest tertiles,

the multivariate relative risks (95% confidence interval) for childhood,

adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80

(0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively.

Inverse associations with childhood intake were noted in all three races, all

three study sites, and women born in Asia and the United States. Adjustment for

measures of westernization attenuated the associations with adolescent and adult

soy intake but did not affect the inverse relationship with childhood soy

intake.DISCUSSION: Soy intake during childhood, adolescence, and adult life was

associated with decreased breast cancer risk, with the strongest, most

consistent effect for childhood intake. Soy may be a hormonally related,

early-life exposure that influences breast cancer incidence. (Cancer Epidemiol

Biomarkers Prev 2009;18(4):OF1-10).

 

PMID: 19318430 [PubMed - as supplied by publisher]

[Guest guest]

It's strange that any of this is new news. It was thoroughly covered in the book

" The China Study " and Dr. Max Gerson reported similar findings decades ago. I

can't understand why people don't get that their toxic diets are causing

diseases and cancers. Americans try to correct diseases caused by bad diets with

chemotherapy and drugs. When they should really be starting off with a correct

diet to avoid getting diseases in the first place.

 

http://rawvegandiet.wordpress.com

 

 

, " heartwerk " <jo.heartwork wrote:

>

>

>

> http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

>

> Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover RN,

Ziegler RG.

>

> Clinical Genetics Branch and Epidemiology and Biostatistics Program, Division

of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda,

Maryland; University of Southern California School of Medicine, Los Angeles,

California; Epidemiology Program, University of Hawaii, Honolulu, Hawaii; and

Northern California Cancer Center, Fremont, California.

>

> INTRODUCTION: Historically, breast cancer incidence has been substantially

higher in the United States than in Asia. When Asian women migrate to the United

States, their breast cancer risk increases over several generations and

approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be

responsible.METHODS: In this population-based case-control study of breast

cancer among women of Chinese, Japanese, and Filipino descent, ages 20 to 55

years, and living in San Francisco-Oakland (California), Los Angeles

(California) and Oahu (Hawaii), we interviewed 597 cases (70% of those eligible)

and 966 controls (75%) about adolescent and adult diet and cultural practices.

For subjects with mothers living in the United States (39% of participants), we

interviewed mothers of 99 cases (43% of eligible) and 156 controls (40%) about

the daughter's childhood exposures. Seventy-three percent of study participants

were premenopausal at diagnosis.RESULTS: Comparing highest with lowest tertiles,

the multivariate relative risks (95% confidence interval) for childhood,

adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80

(0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively.

Inverse associations with childhood intake were noted in all three races, all

three study sites, and women born in Asia and the United States. Adjustment for

measures of westernization attenuated the associations with adolescent and adult

soy intake but did not affect the inverse relationship with childhood soy

intake.DISCUSSION: Soy intake during childhood, adolescence, and adult life was

associated with decreased breast cancer risk, with the strongest, most

consistent effect for childhood intake. Soy may be a hormonally related,

early-life exposure that influences breast cancer incidence. (Cancer Epidemiol

Biomarkers Prev 2009;18(4):OF1-10).

>

> PMID: 19318430 [PubMed - as supplied by publisher]

>

[Guest guest]

Hi Terry

 

I'm not sure this is new news - it's from a vegan site (can't remember which

one). We had been talking about this a few weeks ago and it still seems to

worry some that soya might be bad for us, so I thought I would post it.

 

Jo

 

, " Terry " <aleydesign wrote:

>

> It's strange that any of this is new news. It was thoroughly covered in the

book " The China Study " and Dr. Max Gerson reported similar findings decades ago.

I can't understand why people don't get that their toxic diets are causing

diseases and cancers. Americans try to correct diseases caused by bad diets with

chemotherapy and drugs. When they should really be starting off with a correct

diet to avoid getting diseases in the first place.

>

> http://rawvegandiet.wordpress.com

>

>

> , " heartwerk " <jo.heartwork@> wrote:

> >

> >

> >

> > http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

> >

> > Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover

RN, Ziegler RG.

> >

> > Clinical Genetics Branch and Epidemiology and Biostatistics Program,

Division of Cancer Epidemiology and Genetics, National Cancer Institute,

Bethesda, Maryland; University of Southern California School of Medicine, Los

Angeles, California; Epidemiology Program, University of Hawaii, Honolulu,

Hawaii; and Northern California Cancer Center, Fremont, California.

> >

> > INTRODUCTION: Historically, breast cancer incidence has been substantially

higher in the United States than in Asia. When Asian women migrate to the United

States, their breast cancer risk increases over several generations and

approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be

responsible.METHODS: In this population-based case-control study of breast

cancer among women of Chinese, Japanese, and Filipino descent, ages 20 to 55

years, and living in San Francisco-Oakland (California), Los Angeles

(California) and Oahu (Hawaii), we interviewed 597 cases (70% of those eligible)

and 966 controls (75%) about adolescent and adult diet and cultural practices.

For subjects with mothers living in the United States (39% of participants), we

interviewed mothers of 99 cases (43% of eligible) and 156 controls (40%) about

the daughter's childhood exposures. Seventy-three percent of study participants

were premenopausal at diagnosis.RESULTS: Comparing highest with lowest tertiles,

the multivariate relative risks (95% confidence interval) for childhood,

adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80

(0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively.

Inverse associations with childhood intake were noted in all three races, all

three study sites, and women born in Asia and the United States. Adjustment for

measures of westernization attenuated the associations with adolescent and adult

soy intake but did not affect the inverse relationship with childhood soy

intake.DISCUSSION: Soy intake during childhood, adolescence, and adult life was

associated with decreased breast cancer risk, with the strongest, most

consistent effect for childhood intake. Soy may be a hormonally related,

early-life exposure that influences breast cancer incidence. (Cancer Epidemiol

Biomarkers Prev 2009;18(4):OF1-10).

> >

> > PMID: 19318430 [PubMed - as supplied by publisher]

> >

>

[Guest guest]

Hi Jo - I wasn't being critical of your post. I was trying to remark that people eating a mainstream American diet get cancer, and they don't understand the connection to diet. They always try to pin the blame on something else. Most of the people I know who eat a standard American diet, don't care for soy milk. And if they do like it, it's the sugared up versions. I've heard that soy can cause hormonal imbalances. (Not sure I believe this.) I can't imagine a carton of soy that contains only soy and filtered water is bad for a person. Especially in comparison to cow's milk, which is horrible for a person. I referred to my diet bible " The China Study " regarding studies on rats - diets with 20% soy protein vs. 20% casein (milk protein). The rats fed 20% milk protein had something like 7-8 times more cancer initiation than soy protein. I'm making an educated guess by looking at the chart which doesn't show the exact number. This isn't a study on humans, but to me it appears even with a very high dosage of soy protein, it has very little if any effect on increasing cancer. And people who drink soy milk tend to be healthier eaters, which might explain the lower cancer incidence. Remind me to become a scientist in my next life.

-Terryhttp://rawvegandiet.wordpress.comOn Thu, Apr 2, 2009 at 11:36 PM, heartwerk <jo.heartwork wrote:

 

 

 

 

 

Hi Terry

 

I'm not sure this is new news - it's from a vegan site (can't remember which one). We had been talking about this a few weeks ago and it still seems to worry some that soya might be bad for us, so I thought I would post it.

 

Jo

 

, " Terry " <aleydesign wrote:

>

> It's strange that any of this is new news. It was thoroughly covered in the book " The China Study " and Dr. Max Gerson reported similar findings decades ago. I can't understand why people don't get that their toxic diets are causing diseases and cancers. Americans try to correct diseases caused by bad diets with chemotherapy and drugs. When they should really be starting off with a correct diet to avoid getting diseases in the first place.

>

> http://rawvegandiet.wordpress.com

>

>

> , " heartwerk " <jo.heartwork@> wrote:

> >

> >

> >

> > http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

> >

> > Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC, Hoover RN, Ziegler RG.

> >

> > Clinical Genetics Branch and Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; University of Southern California School of Medicine, Los Angeles, California; Epidemiology Program, University of Hawaii, Honolulu, Hawaii; and Northern California Cancer Center, Fremont, California.

> >

> > INTRODUCTION: Historically, breast cancer incidence has been substantially higher in the United States than in Asia. When Asian women migrate to the United States, their breast cancer risk increases over several generations and approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be responsible.METHODS: In this population-based case-control study of breast cancer among women of Chinese, Japanese, and Filipino descent, ages 20 to 55 years, and living in San Francisco-Oakland (California), Los Angeles (California) and Oahu (Hawaii), we interviewed 597 cases (70% of those eligible) and 966 controls (75%) about adolescent and adult diet and cultural practices. For subjects with mothers living in the United States (39% of participants), we interviewed mothers of 99 cases (43% of eligible) and 156 controls (40%) about the daughter's childhood exposures. Seventy-three percent of study participants were premenopausal at diagnosis.RESULTS: Comparing highest with lowest tertiles, the multivariate relative risks (95% confidence interval) for childhood, adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively. Inverse associations with childhood intake were noted in all three races, all three study sites, and women born in Asia and the United States. Adjustment for measures of westernization attenuated the associations with adolescent and adult soy intake but did not affect the inverse relationship with childhood soy intake.DISCUSSION: Soy intake during childhood, adolescence, and adult life was associated with decreased breast cancer risk, with the strongest, most consistent effect for childhood intake. Soy may be a hormonally related, early-life exposure that influences breast cancer incidence. (Cancer Epidemiol Biomarkers Prev 2009;18(4):OF1-10).

> >

> > PMID: 19318430 [PubMed - as supplied by publisher]

> >

>

[Guest guest]

Hi Terry

 

I knew you weren't being critical, and I do agree with what you say about the

average diet.

 

Jo

 

, Terry Aley <aleydesign wrote:

>

> Hi Jo - I wasn't being critical of your post. I was trying to remark that

> people eating a mainstream American diet get cancer, and they don't

> understand the connection to diet. They always try to pin the blame on

> something else. Most of the people I know who eat a standard American diet,

> don't care for soy milk. And if they do like it, it's the sugared up

> versions. I've heard that soy can cause hormonal imbalances. (Not sure I

> believe this.) I can't imagine a carton of soy that contains only soy and

> filtered water is bad for a person. Especially in comparison to cow's milk,

> which is horrible for a person. I referred to my diet bible " The China

> Study " regarding studies on rats - diets with 20% soy protein vs. 20% casein

> (milk protein). The rats fed 20% milk protein had something like 7-8 times

> more cancer initiation than soy protein. I'm making an educated guess by

> looking at the chart which doesn't show the exact number. This isn't a study

> on humans, but to me it appears even with a very high dosage of soy protein,

> it has very little if any effect on increasing cancer. And people who drink

> soy milk tend to be healthier eaters, which might explain the lower cancer

> incidence. Remind me to become a scientist in my next life.

> -Terry

> http://rawvegandiet.wordpress.com

>

> On Thu, Apr 2, 2009 at 11:36 PM, heartwerk <jo.heartwork wrote:

>

> > Hi Terry

> >

> > I'm not sure this is new news - it's from a vegan site (can't remember

> > which one). We had been talking about this a few weeks ago and it still

> > seems to worry some that soya might be bad for us, so I thought I would post

> > it.

> >

> > Jo

> >

> > <%40>, " Terry "

> > <aleydesign@> wrote:

> > >

> > > It's strange that any of this is new news. It was thoroughly covered in

> > the book " The China Study " and Dr. Max Gerson reported similar findings

> > decades ago. I can't understand why people don't get that their toxic diets

> > are causing diseases and cancers. Americans try to correct diseases caused

> > by bad diets with chemotherapy and drugs. When they should really be

> > starting off with a correct diet to avoid getting diseases in the first

> > place.

> > >

> > > http://rawvegandiet.wordpress.com

> > >

> > >

> > > <%40>,

> > " heartwerk " <jo.heartwork@> wrote:

> > > >

> > > >

> > > >

> > > > http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

> > > >

> > > > Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC,

> > Hoover RN, Ziegler RG.

> > > >

> > > > Clinical Genetics Branch and Epidemiology and Biostatistics Program,

> > Division of Cancer Epidemiology and Genetics, National Cancer Institute,

> > Bethesda, Maryland; University of Southern California School of Medicine,

> > Los Angeles, California; Epidemiology Program, University of Hawaii,

> > Honolulu, Hawaii; and Northern California Cancer Center, Fremont,

> > California.

> > > >

> > > > INTRODUCTION: Historically, breast cancer incidence has been

> > substantially higher in the United States than in Asia. When Asian women

> > migrate to the United States, their breast cancer risk increases over

> > several generations and approaches that for U.S. Whites. Thus, modifiable

> > factors, such as diet, may be responsible.METHODS: In this population-based

> > case-control study of breast cancer among women of Chinese, Japanese, and

> > Filipino descent, ages 20 to 55 years, and living in San Francisco-Oakland

> > (California), Los Angeles (California) and Oahu (Hawaii), we interviewed 597

> > cases (70% of those eligible) and 966 controls (75%) about adolescent and

> > adult diet and cultural practices. For subjects with mothers living in the

> > United States (39% of participants), we interviewed mothers of 99 cases (43%

> > of eligible) and 156 controls (40%) about the daughter's childhood

> > exposures. Seventy-three percent of study participants were premenopausal at

> > diagnosis.RESULTS: Comparing highest with lowest tertiles, the multivariate

> > relative risks (95% confidence interval) for childhood, adolescent, and

> > adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08;

> > Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively. Inverse

> > associations with childhood intake were noted in all three races, all three

> > study sites, and women born in Asia and the United States. Adjustment for

> > measures of westernization attenuated the associations with adolescent and

> > adult soy intake but did not affect the inverse relationship with childhood

> > soy intake.DISCUSSION: Soy intake during childhood, adolescence, and adult

> > life was associated with decreased breast cancer risk, with the strongest,

> > most consistent effect for childhood intake. Soy may be a hormonally

> > related, early-life exposure that influences breast cancer incidence.

> > (Cancer Epidemiol Biomarkers Prev 2009;18(4):OF1-10).

> > > >

> > > > PMID: 19318430 [PubMed - as supplied by publisher]

> > > >

> > >

> >

> >

> >

>

[Guest guest]

I never could drink milk or eat cheese it makes me ill. I have heard a lot of

bad reports about its effect on health. I'm surprised that so many people

consume it.

 

 

 

, Terry Aley <aleydesign wrote:

>

> Hi Jo - I wasn't being critical of your post. I was trying to remark that

> people eating a mainstream American diet get cancer, and they don't

> understand the connection to diet. They always try to pin the blame on

> something else. Most of the people I know who eat a standard American diet,

> don't care for soy milk. And if they do like it, it's the sugared up

> versions. I've heard that soy can cause hormonal imbalances. (Not sure I

> believe this.) I can't imagine a carton of soy that contains only soy and

> filtered water is bad for a person. Especially in comparison to cow's milk,

> which is horrible for a person. I referred to my diet bible " The China

> Study " regarding studies on rats - diets with 20% soy protein vs. 20% casein

> (milk protein). The rats fed 20% milk protein had something like 7-8 times

> more cancer initiation than soy protein. I'm making an educated guess by

> looking at the chart which doesn't show the exact number. This isn't a study

> on humans, but to me it appears even with a very high dosage of soy protein,

> it has very little if any effect on increasing cancer. And people who drink

> soy milk tend to be healthier eaters, which might explain the lower cancer

> incidence. Remind me to become a scientist in my next life.

> -Terry

> http://rawvegandiet.wordpress.com

>

> On Thu, Apr 2, 2009 at 11:36 PM, heartwerk <jo.heartwork wrote:

>

> > Hi Terry

> >

> > I'm not sure this is new news - it's from a vegan site (can't remember

> > which one). We had been talking about this a few weeks ago and it still

> > seems to worry some that soya might be bad for us, so I thought I would post

> > it.

> >

> > Jo

> >

> > <%40>, " Terry "

> > <aleydesign@> wrote:

> > >

> > > It's strange that any of this is new news. It was thoroughly covered in

> > the book " The China Study " and Dr. Max Gerson reported similar findings

> > decades ago. I can't understand why people don't get that their toxic diets

> > are causing diseases and cancers. Americans try to correct diseases caused

> > by bad diets with chemotherapy and drugs. When they should really be

> > starting off with a correct diet to avoid getting diseases in the first

> > place.

> > >

> > > http://rawvegandiet.wordpress.com

> > >

> > >

> > > <%40>,

> > " heartwerk " <jo.heartwork@> wrote:

> > > >

> > > >

> > > >

> > > > http://www.ncbi.nlm.nih.gov/pubmed/19318430?dopt=Abstract

> > > >

> > > > Korde LA, Wu AH, Fears T, Nomura AM, West DW, Kolonel LN, Pike MC,

> > Hoover RN, Ziegler RG.

> > > >

> > > > Clinical Genetics Branch and Epidemiology and Biostatistics Program,

> > Division of Cancer Epidemiology and Genetics, National Cancer Institute,

> > Bethesda, Maryland; University of Southern California School of Medicine,

> > Los Angeles, California; Epidemiology Program, University of Hawaii,

> > Honolulu, Hawaii; and Northern California Cancer Center, Fremont,

> > California.

> > > >

> > > > INTRODUCTION: Historically, breast cancer incidence has been

> > substantially higher in the United States than in Asia. When Asian women

> > migrate to the United States, their breast cancer risk increases over

> > several generations and approaches that for U.S. Whites. Thus, modifiable

> > factors, such as diet, may be responsible.METHODS: In this population-based

> > case-control study of breast cancer among women of Chinese, Japanese, and

> > Filipino descent, ages 20 to 55 years, and living in San Francisco-Oakland

> > (California), Los Angeles (California) and Oahu (Hawaii), we interviewed 597

> > cases (70% of those eligible) and 966 controls (75%) about adolescent and

> > adult diet and cultural practices. For subjects with mothers living in the

> > United States (39% of participants), we interviewed mothers of 99 cases (43%

> > of eligible) and 156 controls (40%) about the daughter's childhood

> > exposures. Seventy-three percent of study participants were premenopausal at

> > diagnosis.RESULTS: Comparing highest with lowest tertiles, the multivariate

> > relative risks (95% confidence interval) for childhood, adolescent, and

> > adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08;

> > Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively. Inverse

> > associations with childhood intake were noted in all three races, all three

> > study sites, and women born in Asia and the United States. Adjustment for

> > measures of westernization attenuated the associations with adolescent and

> > adult soy intake but did not affect the inverse relationship with childhood

> > soy intake.DISCUSSION: Soy intake during childhood, adolescence, and adult

> > life was associated with decreased breast cancer risk, with the strongest,

> > most consistent effect for childhood intake. Soy may be a hormonally

> > related, early-life exposure that influences breast cancer incidence.

> > (Cancer Epidemiol Biomarkers Prev 2009;18(4):OF1-10).

> > > >

> > > > PMID: 19318430 [PubMed - as supplied by publisher]

> > > >

> > >

> >

> >

> >

>